Poster Session/Reception Exhibits Open
Monday, November 9, 2015: 5:00 PM-7:30 PM
Grand Ballroom A-E (Hilton Clearwater Beach Hotel)
Conveners:
Ali Mohagheghi
- National Renewable Energy Laboratory
and
Qiang Fei
- National Renewable Energy Laboratory
Poster Session/Reception Exhibits Open
The use of chemostat experiments to measure and analyze the growth dynamics of microorganisms: Inferring from in-vitro experiments to the state in the gut microbiota in-vivo
G. Jona*, Weizmann Institute of Science, Rehovot, Israel; T. Korem, D. Zeevi, J. Suez, A. Weinberger, T. Avnit-Sagi, M. Pompan-Lotan, E. Matot, A. Harmelin, N. Cohen, C. Thaiss, M. Pevsner, R. Sorek, E. Elinav and E. Segal, Weizmann Institute of Science, Rehovot; A. Sirota-Madi, Massachusetts General Hospital, Harvard Medical School and Broad Institute, Cambridge, MA; R. Xavier, Massachusetts General Hospital, Harvard Medical School and Broad Institute, Cambridge
G. Jona*, Weizmann Institute of Science, Rehovot, Israel; T. Korem, D. Zeevi, J. Suez, A. Weinberger, T. Avnit-Sagi, M. Pompan-Lotan, E. Matot, A. Harmelin, N. Cohen, C. Thaiss, M. Pevsner, R. Sorek, E. Elinav and E. Segal, Weizmann Institute of Science, Rehovot; A. Sirota-Madi, Massachusetts General Hospital, Harvard Medical School and Broad Institute, Cambridge, MA; R. Xavier, Massachusetts General Hospital, Harvard Medical School and Broad Institute, Cambridge
Non-Traditional Fermentation: Solid State Fermentation, Alternative Feedstock for Fermentation, Syngas, and ...
Initial experiments employing fed-batch fermentation of Rhodococcus rhodochrous DAP 96253 with activity against selected fungi
C. Barlament*, C. Wang, K. Cannon and C. Cornelison, Georgia State Univeristy, Atlanta, GA; S.A. Crow Jr. and G.E. Pierce, Georgia State University, Atlanta, GA
C. Barlament*, C. Wang, K. Cannon and C. Cornelison, Georgia State Univeristy, Atlanta, GA; S.A. Crow Jr. and G.E. Pierce, Georgia State University, Atlanta, GA
Quality by Design (QbD) and Design of Experiments for Development: Elements, Regulatory Requirements and Tools
The Use of Design of Experiments to Evaluate an Escherichia coli strain Under Different Fermentation Process Conditions
P.J. Ramsey, North Haven Group, Brookline, NH, F. Agbogbo*, Cytovance Biologics, Oklahoma City, MD and J. McCool, Cytovance Biologics, Oklahoma
P.J. Ramsey, North Haven Group, Brookline, NH, F. Agbogbo*, Cytovance Biologics, Oklahoma City, MD and J. McCool, Cytovance Biologics, Oklahoma
The Use of Raman Spectroscopy for Real-time In situ Monitoring of Multiple Biochemicals During Microbial Process Development
S. Gilliam*, Kaiser Optical Systems, Inc., Ann Arbor, MI; J. Aon and J. Sun, GlaxoSmithKline, King of Prussia, PA
S. Gilliam*, Kaiser Optical Systems, Inc., Ann Arbor, MI; J. Aon and J. Sun, GlaxoSmithKline, King of Prussia, PA
Disruptive Technologies: Delivering Innovation to Fermentation
Dynamic automated feeding control - moving forward with an in-situ metabolic activity sensor
G. Emmerson, Stratophase Ltd, Romsey, United Kingdom of Great Britain and Northern Ireland, S. Watts, Stratophase Ltd, Romsey, United Kingdom and G. Barringer*, Stratophase Ltd (USA), W Groton, MA, United Kingdom
G. Emmerson, Stratophase Ltd, Romsey, United Kingdom of Great Britain and Northern Ireland, S. Watts, Stratophase Ltd, Romsey, United Kingdom and G. Barringer*, Stratophase Ltd (USA), W Groton, MA, United Kingdom
Fermentation Education and People Development: Looking to our Future and Today
Worcester Polytechnic Institute provides holistic solutions to the fermentation industry
K. Rashid* and R. LeBlanc, Worcester Polytechnic Institute, Worcester, MA
K. Rashid* and R. LeBlanc, Worcester Polytechnic Institute, Worcester, MA
Rewards and Challenges of Scale-up and Large Scale Fermentation Processes
Development of an on-line state estimator for fed-batch filamentous fungal fermentations
L. Mears*, G. Sin and K.V. Gernaey, Technical University of Denmark, Kgs. Lyngby, Denmark; S.M. Stocks and M.O. Albaek, Novozymes A/S, Bagsværd, Denmark
L. Mears*, G. Sin and K.V. Gernaey, Technical University of Denmark, Kgs. Lyngby, Denmark; S.M. Stocks and M.O. Albaek, Novozymes A/S, Bagsværd, Denmark
Upstream Screening and Early Process Development Strategies and Technologies
Online and non-invasive measurement of biomass in shake flask: concept and application
G. John*, PreSens Precision Sensing GmbH, Regensburg, Germany and S. Beutel, Gottfried Wilhelm Leibniz Universität Hannover, Hannover
G. John*, PreSens Precision Sensing GmbH, Regensburg, Germany and S. Beutel, Gottfried Wilhelm Leibniz Universität Hannover, Hannover
Rewards and Challenges of Scale-up and Large Scale Fermentation Processes
Cellulases and xylanases production by Humicola grisea var. thermoidea on different lignocellulosic substrates and their application in hemicelullase hydrolysis of sugar cane bagasse
A. Gregorim Fernandes*, L. Cardoso Cintra, S. Pereira Faria and M.J. Poças Fonseca, University of Brasilia, Brasilia; G. Ramos Melo, R. Santos Amorim Jesuíno and F. Paula de Faria, Federal University of Goiás, Goiânia
A. Gregorim Fernandes*, L. Cardoso Cintra, S. Pereira Faria and M.J. Poças Fonseca, University of Brasilia, Brasilia; G. Ramos Melo, R. Santos Amorim Jesuíno and F. Paula de Faria, Federal University of Goiás, Goiânia
Process development and scale-up of a novel high cell-density fermentation for protein production
F. Tachea*, A. Narani, C.S. Chen and D. Tanjore, Lawrence Berkeley National Laboratory, Emeryville, CA; H. Chen, R. Pandya and P. Gandhi, Muufri, Menlo Park, CA; P. Coffman and T. Pray, Lawrence Berkeley National Laboratory, Berkeley, CA
F. Tachea*, A. Narani, C.S. Chen and D. Tanjore, Lawrence Berkeley National Laboratory, Emeryville, CA; H. Chen, R. Pandya and P. Gandhi, Muufri, Menlo Park, CA; P. Coffman and T. Pray, Lawrence Berkeley National Laboratory, Berkeley, CA
Upstream Screening and Early Process Development Strategies and Technologies
High-level production of synthetic proteins containing non-canonical amino acids
P. Fladischer*, N. Anderhuber, O. Murgu and B. Wiltschi, acib - Austrian Centre of Industrial Biotechnology, Graz; M. Gruber-Khadjawi, Fresenius Kabi Pharma Austria GmbH, Graz; R. Birner-Gruenberger, Medical University of Graz, Graz; A. Hromic, T. Pavkov-Keller and K. Gruber, University of Graz, Graz; J. Mairhofer, enGenes Biotech GmbH, Vienna; G. Striedner, University of Natural Resources and Life Sciences, Vienna, Austria
P. Fladischer*, N. Anderhuber, O. Murgu and B. Wiltschi, acib - Austrian Centre of Industrial Biotechnology, Graz; M. Gruber-Khadjawi, Fresenius Kabi Pharma Austria GmbH, Graz; R. Birner-Gruenberger, Medical University of Graz, Graz; A. Hromic, T. Pavkov-Keller and K. Gruber, University of Graz, Graz; J. Mairhofer, enGenes Biotech GmbH, Vienna; G. Striedner, University of Natural Resources and Life Sciences, Vienna, Austria
Poster Session/Reception Exhibits Open
New miniature on-line optical cell biomass probe with wide linear range and bubble discrimination
M. Debreczeny, G. Coleman and C. Gonzales*, BugLab LLC, Concord, CA
M. Debreczeny, G. Coleman and C. Gonzales*, BugLab LLC, Concord, CA
Upstream Screening and Early Process Development Strategies and Technologies
Use of single-cell analysis and recombinant protein - GFP fusions to optimise recombinant protein production
C. Wyre, N.A. Hasliza Zulkifly and T. Overton*, University of Birmingham, Birmingham; T. Selas Castineiras, University of Birmingham / Cobra Biologics Ltd., Birmingham / Keele
C. Wyre, N.A. Hasliza Zulkifly and T. Overton*, University of Birmingham, Birmingham; T. Selas Castineiras, University of Birmingham / Cobra Biologics Ltd., Birmingham / Keele
Optimisation of fermentation conditions for the production of soluble and active tumour necrosis factor α in Escherichia coli
T. Selas Castineiras*, University of Birmingham / Cobra Biologics Ltd., Birmingham / Keele; S. Williams, T. Hitchcock and D. Smith, Cobra Biologics, Keele; J.A. Cole and T. Overton, University of Birmingham, Birmingham
T. Selas Castineiras*, University of Birmingham / Cobra Biologics Ltd., Birmingham / Keele; S. Williams, T. Hitchcock and D. Smith, Cobra Biologics, Keele; J.A. Cole and T. Overton, University of Birmingham, Birmingham
Development of an Escherichia coli extracellular expression system
T. Aldrich*, I. Leung and M. Tai, ZymoGenetics, a Bristol-Myers Squibb Company, Seattle, WA; M. Ly, Amgen, Cambridge, MA
T. Aldrich*, I. Leung and M. Tai, ZymoGenetics, a Bristol-Myers Squibb Company, Seattle, WA; M. Ly, Amgen, Cambridge, MA
Filamentous fungi as cell factories for protein production
K. Overkamp*, Dutch DNA Biotech, Zeist and P.J. Punt, TNO, Zeist, Netherlands
K. Overkamp*, Dutch DNA Biotech, Zeist and P.J. Punt, TNO, Zeist, Netherlands
CHO clarification of a 500 L SUB in less than three hours with UniFuge® Single Use Centrifuge
D. Richardson*, PSAngelus- CArr/ Centritech, Clearwater, FL and P. Motulewicz, PSAngelus, Clearwater, FL
D. Richardson*, PSAngelus- CArr/ Centritech, Clearwater, FL and P. Motulewicz, PSAngelus, Clearwater, FL
Research on development of farm/field-deployable bioreactor process for conversion of biomass to saccharides and ethanol
B. Okeke*, Auburn University at Montgomery, Montgomery, AL and A. Nanjundaswamy, Alcorn State University, Lorman, MS
B. Okeke*, Auburn University at Montgomery, Montgomery, AL and A. Nanjundaswamy, Alcorn State University, Lorman, MS
Ethanol inhibited xylose catabolismon by Saccharomyces cerevisiae and in situ removal resulted in high production of cellulosic ethanol
B. Zhang, H. Sun and Y. Zhang*, Institute of Microbiology, Chinese Academy of Sciences, Beijing
B. Zhang, H. Sun and Y. Zhang*, Institute of Microbiology, Chinese Academy of Sciences, Beijing
Development of an Escherichia coli Recombinant Protein Fermentation Process
M. Yamada*, K. Veeravalli and R. Hamilton, Genentech, Inc, South San Francisco, CA
M. Yamada*, K. Veeravalli and R. Hamilton, Genentech, Inc, South San Francisco, CA
Mass Production of Ginsenosides in Saccharomyces cerevisiae
S.C. Jung*, M.S. Kim, G. Choi and S.C. Kim, Korea Advanced Institute of Science and Technology, Daejeon, South Korea; J. Baek, Korea Advanced Institute of Science and Technology, Daejeon
S.C. Jung*, M.S. Kim, G. Choi and S.C. Kim, Korea Advanced Institute of Science and Technology, Daejeon, South Korea; J. Baek, Korea Advanced Institute of Science and Technology, Daejeon
Reliable scale-down models combined to high throughput enable DoE studies for faster and improved process optimization
S. Demay*, N. Chaudet and J.M. Guillaume, Sanofi Pasteur, Marcy l'Etoile, France; M. Monnet, Sanofi Pasteur, Marcy l'Etoile
S. Demay*, N. Chaudet and J.M. Guillaume, Sanofi Pasteur, Marcy l'Etoile, France; M. Monnet, Sanofi Pasteur, Marcy l'Etoile
Development of a chemically defined medium that allows high growth rates and protein expression in E. coli.
F. Inman*, I. Cabrera-Ostertag, M. Wilson and J.F. Menton, Kerry, Beloit, WI
F. Inman*, I. Cabrera-Ostertag, M. Wilson and J.F. Menton, Kerry, Beloit, WI
Field evaluation of a novel automated fed-batch micro bioreactor for fermentation of Pseudomonas fluorescens expressing a biopharmaceutical product
T. Bruck*, Pfenex Inc., San Diego, CA; B. Zoro and J. Betts, Tap Biosystems -Part of Sartorius Stedim Biotech Group, Royston
T. Bruck*, Pfenex Inc., San Diego, CA; B. Zoro and J. Betts, Tap Biosystems -Part of Sartorius Stedim Biotech Group, Royston
Pea protein and pea protein hydrolysate: alternative nitrogen sources for the fermentation industry offering excellent performance
R. Cheng*, E. Lee, D. Wenzel, A. Billa, S. Maubourguet, S. McCann, L. Zhou, T. Feron and L. Pascal, Roquette America Inc., Geneva, IL
R. Cheng*, E. Lee, D. Wenzel, A. Billa, S. Maubourguet, S. McCann, L. Zhou, T. Feron and L. Pascal, Roquette America Inc., Geneva, IL
Isopropanol production from biomass-derived sugars by metabolically engineered Escherichia coli
V. Sanchez i Nogue*, B.A. Black, D. Salvachua, E.M. Karp and G.T. Beckham, National Renewable Energy Laboratory, Golden, CO
V. Sanchez i Nogue*, B.A. Black, D. Salvachua, E.M. Karp and G.T. Beckham, National Renewable Energy Laboratory, Golden, CO
The role of yeast extract in the expression of intrinsically disordered proteins in Escherichia coli
L. Jacob*, SENSIENT TECHNOLOGIES, Hoffman Estates, IL; K. Churion and S. Bondos, Texas A&M University, College Station, TX
L. Jacob*, SENSIENT TECHNOLOGIES, Hoffman Estates, IL; K. Churion and S. Bondos, Texas A&M University, College Station, TX
Rewards and Challenges of Scale-up and Large Scale Fermentation Processes
Recent developments in using single use probes for measuring the live cell concentration by dielectric spectroscopy
J. Carvell* and A. Bhat, Aber Instruments, Aberystwyth
J. Carvell* and A. Bhat, Aber Instruments, Aberystwyth
Collection of Stem cells Using the UniFuge® Single Use Centrifuge
D. Richardson*, PSAngelus- CArr/ Centritech, Clearwater, FL and P. Motulewicz, PSAngelus, Clearwater, FL
D. Richardson*, PSAngelus- CArr/ Centritech, Clearwater, FL and P. Motulewicz, PSAngelus, Clearwater, FL
Optimizing operation of a single-product, multi-fermentor plant
W. van Winden*, DSM Biotechnology Center, Delft, The Netherlands, Netherlands
W. van Winden*, DSM Biotechnology Center, Delft, The Netherlands, Netherlands
DNA Half-Life Measurements for Fermentation Biomass Applied to Farm Fields as a Fertilizer for Corn and Fescue Crops
M. Halter* and J. Zahn, Dupont Tate & Lyle Bio Products, LLC, Loudon, TN; G. Card, DuPont Tate & Lyle Bio Products, LLC, Loudon, TN
M. Halter* and J. Zahn, Dupont Tate & Lyle Bio Products, LLC, Loudon, TN; G. Card, DuPont Tate & Lyle Bio Products, LLC, Loudon, TN
Innovative technologies applied in the advanced bioprocess development and manufacturing
P. Jiao*, Boston Institute of Biotechnology, Southborough, MA
P. Jiao*, Boston Institute of Biotechnology, Southborough, MA
Successful bioprocess scale-up from small scale to large pilot scale using Eppendorf bioprocess systems
B. Li* and M. Sha, Eppendorf, Inc., Enfield, CT
B. Li* and M. Sha, Eppendorf, Inc., Enfield, CT
Hydrodynamic characterization of substrate gradients in a pilot scale fermenter using CFD and spatially distributed sensors
C. Bach*, U. Krühne and K.V. Gernaey, Technical University of Denmark, Kgs. Lyngby, Denmark; M.O. Albaek, Novozymes A/S, Bagsværd, Denmark
C. Bach*, U. Krühne and K.V. Gernaey, Technical University of Denmark, Kgs. Lyngby, Denmark; M.O. Albaek, Novozymes A/S, Bagsværd, Denmark
Fermentation development of a secondary metabolite: applying multiple tools in an integrated bioprocess development program to accelerate process improvements
D. Brown*, Dow AgroSciences LLC, Indianapolis
D. Brown*, Dow AgroSciences LLC, Indianapolis
Chemically defined media development for Escherichia coli fermentation
J. Burr*, Genentech, Inc., South San Francisco, CA and R. Hamilton, Genentech, Inc, South San Francisco, CA
J. Burr*, Genentech, Inc., South San Francisco, CA and R. Hamilton, Genentech, Inc, South San Francisco, CA
Effect of fermentation parameters during scale-up on enzyme stability
A. Bedekar*, DuPont Industrial Biosciences, Palo Alto, CA
A. Bedekar*, DuPont Industrial Biosciences, Palo Alto, CA
A comparison of Escherichia coli fermentations run in the ambr®250 and 100L stainless steel vessels: confirming scalability for process development
F. Slingsby*, S. Thomas, D. Seales, S. Dewar and A. Weiss, Fujifilm Diosynth Biotechnologies, Billingham
F. Slingsby*, S. Thomas, D. Seales, S. Dewar and A. Weiss, Fujifilm Diosynth Biotechnologies, Billingham
Finding the missing link in complete Single use fermentation line: evaluation of single use large scale bioreactors for aerobic bacteria
N. Chaudet* and J.M. Guillaume, Sanofi Pasteur, Marcy l'Etoile, France; M. Monnet and G. Exbrayat, Sanofi Pasteur, Marcy l'Etoile
N. Chaudet* and J.M. Guillaume, Sanofi Pasteur, Marcy l'Etoile, France; M. Monnet and G. Exbrayat, Sanofi Pasteur, Marcy l'Etoile
Strategies for industrial fermentation process optimization
B. Moss* and X. Cai, Novozymes, Franklinton, NC
B. Moss* and X. Cai, Novozymes, Franklinton, NC
Quantification of spatial heterogeneity in large bioreactors
A. Nørregaard*, Technical university of Denmark, Kgs. Lyngby, K.V. Gernaey, Technical University of Denmark, Kgs. Lyngby, Denmark, S.M. Stocks, Novozymes A/S, Bagsværd, Denmark and B. Madsen, Novo Nordisk A/S, Kalundborg
A. Nørregaard*, Technical university of Denmark, Kgs. Lyngby, K.V. Gernaey, Technical University of Denmark, Kgs. Lyngby, Denmark, S.M. Stocks, Novozymes A/S, Bagsværd, Denmark and B. Madsen, Novo Nordisk A/S, Kalundborg
Scale-down studies of Corynebacterium glutamicum to oscillating substrate and oxygen avalilability in multi-compartment bioreactor sytems
A. Lemoine and R. Spann, TU Berlin, Berlin, Germany; S. Junne and P. Neubauer*, TU Berlin, Berlin, Germany, Germany; F. Schwartz, Sequip S+E, Düsseldorf, Germany
A. Lemoine and R. Spann, TU Berlin, Berlin, Germany; S. Junne and P. Neubauer*, TU Berlin, Berlin, Germany, Germany; F. Schwartz, Sequip S+E, Düsseldorf, Germany
Yeast Extract full definition: a powerful tool to mitigate bioprocess performance
A. Sourabié*, BioSpringer, LESAFFRE Group, Maisons-Alfort, FRANCE; C. Navas, M. Vallet and D. Druaux, Bio Springer, Maisons-Alfort; J. Alferman and L. Soto, Bio Springer North America, Milwaukee, WI
A. Sourabié*, BioSpringer, LESAFFRE Group, Maisons-Alfort, FRANCE; C. Navas, M. Vallet and D. Druaux, Bio Springer, Maisons-Alfort; J. Alferman and L. Soto, Bio Springer North America, Milwaukee, WI
Disruptive Technologies: Delivering Innovation to Fermentation
PAT for upstream bioprocess monitoring and control in real time: information, opportunity, and reality
C. Evans*, ASL Analytical, Coralville, IA
C. Evans*, ASL Analytical, Coralville, IA
Non-Traditional Fermentation: Solid State Fermentation, Alternative Feedstock for Fermentation, Syngas, and ...
Comparative study of succinic acid production from xylose-enriched biorefinery streams by Actinobacillus succinogenes and Basfia succiniciproducens in batch fermentation
H. Smith*, D. Salvachua, A. Mohagheghi, N. Dowe and G. Beckham, National Renewable Energy Laboratory, Golden, CO
H. Smith*, D. Salvachua, A. Mohagheghi, N. Dowe and G. Beckham, National Renewable Energy Laboratory, Golden, CO
Investigation of lipid production by Methylomicrobium buryatense using CH4 as the carbon source
Q. Fei* and P. Pienkos, National Renewable Energy Laboratory, Golden, CO
Q. Fei* and P. Pienkos, National Renewable Energy Laboratory, Golden, CO
Fermentation of sweet sorghum derived sugars to butyric acid at high titer and productivity by a thermophile Clostridium thermobutyricum at 50°C
L. Wang*, university of florida, GAINESVILLE, FL; M. Ou, University of Florida, GAINESVILLE, FL; I.U. Nieves, University of Florida, Perry, FL; J.E. Erickson, W. Vermerris, L.O. Ingram and K.T. Shanmugam, University of Florida, Gainesville, FL
L. Wang*, university of florida, GAINESVILLE, FL; M. Ou, University of Florida, GAINESVILLE, FL; I.U. Nieves, University of Florida, Perry, FL; J.E. Erickson, W. Vermerris, L.O. Ingram and K.T. Shanmugam, University of Florida, Gainesville, FL
Propionic acid fermentation from corn stover hydrolysate by Propionibacterium acidipropionici
X. Wang*, D. Salvachua, E.M. Karp, W. Michener and G. Beckham, National Renewable Energy Laboratory, Golden, CO
X. Wang*, D. Salvachua, E.M. Karp, W. Michener and G. Beckham, National Renewable Energy Laboratory, Golden, CO
Fermentation of juice from sugarcorn, a new feedstock for the ethanol industry
R. Nicol*, D. Young, L. McNea, K. Van Overloop and B. Gilroyed, University of Guelph, Ridgetown, ON; T. Nambi, R. Gomez-Flores and A. Margaritis, University of Western Ontario, London, ON; M. Morrison and L. Reid, Agriculture and Agri-Food Canada, Ottawa, ON
R. Nicol*, D. Young, L. McNea, K. Van Overloop and B. Gilroyed, University of Guelph, Ridgetown, ON; T. Nambi, R. Gomez-Flores and A. Margaritis, University of Western Ontario, London, ON; M. Morrison and L. Reid, Agriculture and Agri-Food Canada, Ottawa, ON
What induces respiration in lactic acid bacteria? Characterization of respiratory metabolism of Lactococcus lactis in bioreactors for production of starter cultures with improved acidification capacity
B. Lorántfy*, C.J. Franzén, L. Olsson and V. Mapelli, Chalmers University of Technology, Gothenburg, Sweden
B. Lorántfy*, C.J. Franzén, L. Olsson and V. Mapelli, Chalmers University of Technology, Gothenburg, Sweden
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