5: Downstream processing and integration with fermentation processes

Tuesday, November 8, 2011: 1:00 PM-4:30 PM
Islands Ballroom G-J (Marriott Marco Island)
Tony Hitchcock
Jesse McCool
1:00 PM
Integrated approaches to process development -the usp/dsp interface
JM Liddell, Fujifilm Diosynth Biotechnologies, Bilingham, United Kingdom
1:30 PM
A novel platform for site-specific modification of E. coli expressed proteins
Grant E. Henderson, Kevin D. Isett and Tillman U. Gerngross, Thayer School of Engineering, Dartmouth College, Hanover, NH
2:00 PM
The interaction of host cell protein dynamics with process variables during the recovery of monoclonal antibodies
Andrew Tait1, Shahina Ahmad1, Cat Hogwood2, C. Mark Smales2 and Daniel G. Bracewell1, (1)Department of Biochemical Engineering, University College London, London, United Kingdom, (2)School of Biosciences and Centre for Molecular Processing, University of Kent, Canterbury, United Kingdom
2:30 PM
3:00 PM
Integration of the Upstream and Downstream Process Development - the Key to Develop a Robust Downstream Process Ready for Technology Transfer and Manufacturing
Yun Bai1, Joe Tuchscherer1 and Becky Tanamachi2, (1)Protein Sciences, Ambrx Inc., La Jolla, CA, (2)Manufacturing, Ambrx Inc., La Jolla, CA
3:30 PM
A platform for IS-free pDNA production: Use of Clean Genome® E. coli for elimination of IS contaminated pDNA therapeutics. 
Steve Palmieri, Mike Panechelli, Dogan Ornek, Maureen Hamilton and Mark Lewandowski, Lonza Biologics, Inc., Hopkinton, MA
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