Tuesday, November 8, 2011: 3:30 PM
Islands Ballroom G-J (Marriott Marco Island)
When plasmids are isolated from E. coli they are typically contaminated with mobile DNA elements called insertion sequences (IS elements). Drug quality, safety and efficacy may be negatively impacted by the presence of IS elements in plasmids. In order to eliminate the IS concern altogether, Lonza has integrated Scarab host technology into its pDNA production platform. Recent improvements to the fermentation and primary recovery steps were made for improved manufacturability. This platform enables the production of IS-free plasmid DNA biotherapeutics.
See more of: Downstream processing and integration with fermentation processes
See more of: Invited Oral Papers
See more of: Invited Oral Papers