P9: Wireless control of fed-batch fermentation systems

Bioreactor operation requires continuous monitoring of fermentation parameters and real-time control over bioreactor devices.  Remote monitoring and control of the bioreactor's computer via the Internet avoids the necessity of personnel being continually on-site during operation.  A Sartorius Biostat A Plus® bioreactor (2 Liter) and its computer control system were interfaced with the commercial software GoToMyPC®. The bioreactor was equipped with all controls for monitoring during experiments:  oxygen sensor, pH sensor, temperature sensor and agitation. Other calibrations (media inflow & outflow, antifoam additions) were calibrated with the system’s peristaltic pump adjusted for time.  Remotely controlled night-vision web cameras allowed monitoring capability of the glass fermentation vessel.  A Wi-Fi connection via wireless router allowed multiple system connections to the host computer.  The window screen of the main computer can be accessed from any wireless device with an Internet connection. The secured Internet Protocol (IP) address assures that the system can only be controlled by the main users. This wireless interface permits the remote control of fed-batch fermentations and other culturing protocols.