S32: Improving scalability from lab to industrial scale for enzyme production

Wednesday, November 9, 2011: 10:30 AM
Islands Ballroom G-J (Marriott Marco Island)
Frede Lei1, Xiaofeng Ye1 and Linda Eeg Hansen2, (1)Novozymes North America Inc., Franklinton, NC, (2)Fermentation Optimization DK, Novozymes A/S, Kalundborg, Denmark
To maximize bottom line profits, enzyme producers are continuously optimizing their production in order improve their production costs and capacity. To be most effective in optimization, most trials should be done in small scale to avoid large perturbations in the production execution. Therefore, it is essential that we are able to scale the results we observe in lab scale to production scale to implement our leads successfully. Also, for large production volumes, a  yield improvement of a few percentages represents significant economical valve thus, l yield improvements require good scalability to avoid wasting valuable resources testing poor leads in production scale.

 In this presentation, a practical approach on how to improve scalability for fermentation processes between lab and industry scale is presented. We have expanded our definitely of scalability so we do not only consider the enzyme titer when evaluating scalability. Rather, a successful scalable process also scales factors like e.g tank filling, oxygen transfer, stoichiometric coefficients and other physiological parameters.