Session 1: Upstream Screening and Early Process Development Strategies and Technologies
Sunday, November 8, 2015: 1:00 PM-4:00 PM
Grand Ballroom F-G (Hilton Clearwater Beach Hotel)
David Laidlaw - Kuhner Shaker Inc. and Peter Neubauer - TU Berlin
Your target molecule has been identified… now what? Transformation of research and development leads into commercially-viable fermentation processes pushes the boundaries of our disciplines ingenuity and scientific understanding.  Our knowledge of bioengineering, high throughput assessment and process development science collide at the upstream steps to present a compounded problem of how to quickly and reliably advance the best candidates along a commercial process trail. This session will broadly explore strategies available to those transitioning products from research to early stage process development. Techniques, tools and technologies used to engineer host strains, to explore large numbers of clones and to assess media formulations or fermentation conditions will be discussed from a balance of academic, industrial and equipment-manufacturer perspectives.

1:00 PM
Simultaneous, high dimensional strain engineering and process optimisation for increased productivity and robustness
V. Sanchania, M. Sadowski and S. Ward, Synthace Limited, London; M. Gershater*, Synthace Limited, London, United Kingdom
1:25 PM
Efficient process for the manufacture of enzymes for use in API synthesis
M. Bycroft*, N. Triggs, E. Rackham, I. Taylor, T. Fleming and K. Holt-Tiffin, Dr. Reddy's Laboratories Ltd., Cambridge, UK
1:55 PM
Screening for Optimal Growth Conditions of Pichia Pastoris using the micro-Matrix platform
C. Fernandes, C. Bernal Martinez, P. Ter Huurne and T. Walvoort, Applikon Biotechnology B.V., Delft; A. D'Ambruoso*, Applikon Biotechnology, Inc., Foster City, CA
2:10 PM
Screening under process near conditions
K. Bruellhoff*, PS Biotech, Aachen (Germany)
2:45 PM
Strain Engineering for Robust E. coli Fermentation Processes
K. Veeravalli*, M. Yamada, R. Hamilton and M. Laird, Genentech, Inc, South San Francisco, CA; T. Schindler, Dupont Industrial Biosciences, Wilmington, DE; K. Bodner, Stanford University, Stanford, CA
3:10 PM
3:40 PM
Computer aided model based bioprocess development by automated on-line optimal re-design in parallel bioreactors
P. Neubauer*, M.N. Cruz Bournazou, D. Nickel, T. Barz and A. Knepper, TU Berlin, Berlin
See more of: Invited Papers