Session 8:
Enzyme Science and Technology I: Modeling and Structure/Function
Tuesday, April 28, 2015: 1:00 PM-4:25 PM
Aventine Ballroom DEF, Ballroom Level
Conveners:
Brandon Knott - NREL, Golden, CO
and
Jerry Stahlberg - SLU, Uppsala,
1:00 PM
Structure, function and application of lytic polysaccharide monooxygenases (LPMOs)
Vincent G.H. Eijsink, Bjørge Westereng, Zarah Forsberg, Svein Jarle Horn and Gustav Vaaje-Kolstad, Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Aas, Norway
Vincent G.H. Eijsink, Bjørge Westereng, Zarah Forsberg, Svein Jarle Horn and Gustav Vaaje-Kolstad, Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Aas, Norway
1:25 PM
Expression, crystal structure and cellulase activity of the thermostable cellobiohydrolase Cel7A from the fungus Humicola grisea var. thermoidea
Dr. Jerry Ståhlberg1, Dr. Majid Haddad Momeni1, Dr. Frits Goedegebuur2, Dr. Henrik Hansson1, Dr. Saeid Karkehabadi1, Dr. Edmund Larenas3, Dr. Colin Mitchinson3 and Dr. Mats Sandgren1, (1)Department of Chemistry and Biotechnology, Swedish University of Agricultural Sciences, Uppsala, Sweden, (2)DuPont Industrial Biosciences, Leiden, The Netherlands, (3)DuPont Industrial Biosciences, Palo Alto, CA
Dr. Jerry Ståhlberg1, Dr. Majid Haddad Momeni1, Dr. Frits Goedegebuur2, Dr. Henrik Hansson1, Dr. Saeid Karkehabadi1, Dr. Edmund Larenas3, Dr. Colin Mitchinson3 and Dr. Mats Sandgren1, (1)Department of Chemistry and Biotechnology, Swedish University of Agricultural Sciences, Uppsala, Sweden, (2)DuPont Industrial Biosciences, Leiden, The Netherlands, (3)DuPont Industrial Biosciences, Palo Alto, CA
1:50 PM
Kinetic models of cellulase-lignin interaction: structural contributions to adsorption kinetics
Dr. Katherine Pfeiffer, Chemical and Biomolecular Engineering, UC Berkeley, Berkeley, CA, Prof. Doug Clark, Chemical and Biomolecular Engineering, UC Berkeley and Harvey W. Blanch, Chemical and Biomolecular Engineering, University of California - Berkeley, Berkeley, CA
Dr. Katherine Pfeiffer, Chemical and Biomolecular Engineering, UC Berkeley, Berkeley, CA, Prof. Doug Clark, Chemical and Biomolecular Engineering, UC Berkeley and Harvey W. Blanch, Chemical and Biomolecular Engineering, University of California - Berkeley, Berkeley, CA
2:45 PM
The unexpected importance of actinobacterial GH12 in hydrolysis of crystalline cellulose
Jennifer Hiras1, Yu-Wei Wu1, Susannah G. Tringe2, Carrie Nicora3, Joshua Aldrich4, Errol Robinson4, Jon Jacobs4, Blake Simmons5 and Steven Singer1, (1)Deconstruction Division, Joint BioEnergy Institute, Emeryville, CA, (2)Joint Genome Institute, Walnut Creek, CA, (3)Pacific Northwest National Laboratory, (4)Environmental Molecular Sciences Laboratory, Richland, WA, (5)Deconstruction Division, Joint BioEnergy Institute / Sandia National Laboratories, Emeryville, CA
Jennifer Hiras1, Yu-Wei Wu1, Susannah G. Tringe2, Carrie Nicora3, Joshua Aldrich4, Errol Robinson4, Jon Jacobs4, Blake Simmons5 and Steven Singer1, (1)Deconstruction Division, Joint BioEnergy Institute, Emeryville, CA, (2)Joint Genome Institute, Walnut Creek, CA, (3)Pacific Northwest National Laboratory, (4)Environmental Molecular Sciences Laboratory, Richland, WA, (5)Deconstruction Division, Joint BioEnergy Institute / Sandia National Laboratories, Emeryville, CA
3:10 PM
Prospecting for cellulases from the marine environment: structure and function of novel GH7 and GH9 family glycoside hydrolases
John McGeehan1, Rebecca Fewings1, Ali Ebrahim1, Sam Mallinson1, Anna Swiderska1, Geoff Kneale1, Chenyi Wu1, Simon Cragg1, Sarah E. Hobdey2, Kara Podkaminer2, Larry E. Taylor II2, Stephen R. Decker2, Michael E. Himmel2, Gregg T. Beckham3, Neil Bruce4, Simon McQueen-Mason4, Lars Anderson5, Kirk Schnorr5, Juan Sanchez-Weatherby6 and Thomas Sorensen6, (1)School of Biological Sciences, University of Portsmouth, Portsmouth, UK, (2)Biosciences Center, National Renewable Energy Laboratory, Golden, CO, (3)National Bioenergy Center, National Renewable Energy Laboratory, Golden, CO, (4)CNAP/Department of Biology, University of York, York, (5)Novozymes A/S, Bagsvaerd, DK, (6)Diamond Light Source, Oxfordshire, UK
John McGeehan1, Rebecca Fewings1, Ali Ebrahim1, Sam Mallinson1, Anna Swiderska1, Geoff Kneale1, Chenyi Wu1, Simon Cragg1, Sarah E. Hobdey2, Kara Podkaminer2, Larry E. Taylor II2, Stephen R. Decker2, Michael E. Himmel2, Gregg T. Beckham3, Neil Bruce4, Simon McQueen-Mason4, Lars Anderson5, Kirk Schnorr5, Juan Sanchez-Weatherby6 and Thomas Sorensen6, (1)School of Biological Sciences, University of Portsmouth, Portsmouth, UK, (2)Biosciences Center, National Renewable Energy Laboratory, Golden, CO, (3)National Bioenergy Center, National Renewable Energy Laboratory, Golden, CO, (4)CNAP/Department of Biology, University of York, York, (5)Novozymes A/S, Bagsvaerd, DK, (6)Diamond Light Source, Oxfordshire, UK
3:35 PM
Understanding sugar yield loss and enzyme inhibition due to oligosaccharides accumulation during high solids-loading enzymatic hydrolysis
Saisi Xue1, Nirmal Uppugundla2, Michael J. Bowman3, Mingjie Jin4, Leonardo da Costa Sousa5, Shishir P.S. Chundawat2, Brian Fox6, David Cavalier7, Bruce E. Dale8 and Venkatesh Balan9, (1)Department of Chemical Engineering and Materials Science, Michigan State University, DOE Great Lakes Bioenergy Research Center (GLBRC), East Lansing, MI, (2)Biomass Conversion Research Laboratory, Deparment of Chemical Engineering and Materials Science, DOE Great Lakes Bioenergy Research Center, Michigan State University, Lansing, MI, (3)Bioenergy Research Unit, United States Department of Agriculture, Agricultural Research Service, National Center for Agricultural Utilization Research, Peoria, IL, (4)Chemical Engineering and Materials Science, Michigan State University, DOE Great Lakes Bioenergy Research Center, Lansing, MI, (5)Department of Chemical Engineering and Materials Science,, Michigan State University and University of Pune, Lansing, MI, (6)Department of Biochemistry, University of Wisconsin-Madison, DOE Great Lakes Bioenergy Research Center, Madison, WI, (7)DOE Plant Research Laboratory, Michigan State University, East Lansing, MI, (8)Chemical Engineering and Materials Science, DOE Great Lakes Bioenergy Research Center, Michigan State University, Lansing, MI, (9)Department of Chemical Engineering and Materials Science, Michigan State University, DOE Great Lakes Bioenergy Research Center, Lansing, MI
Saisi Xue1, Nirmal Uppugundla2, Michael J. Bowman3, Mingjie Jin4, Leonardo da Costa Sousa5, Shishir P.S. Chundawat2, Brian Fox6, David Cavalier7, Bruce E. Dale8 and Venkatesh Balan9, (1)Department of Chemical Engineering and Materials Science, Michigan State University, DOE Great Lakes Bioenergy Research Center (GLBRC), East Lansing, MI, (2)Biomass Conversion Research Laboratory, Deparment of Chemical Engineering and Materials Science, DOE Great Lakes Bioenergy Research Center, Michigan State University, Lansing, MI, (3)Bioenergy Research Unit, United States Department of Agriculture, Agricultural Research Service, National Center for Agricultural Utilization Research, Peoria, IL, (4)Chemical Engineering and Materials Science, Michigan State University, DOE Great Lakes Bioenergy Research Center, Lansing, MI, (5)Department of Chemical Engineering and Materials Science,, Michigan State University and University of Pune, Lansing, MI, (6)Department of Biochemistry, University of Wisconsin-Madison, DOE Great Lakes Bioenergy Research Center, Madison, WI, (7)DOE Plant Research Laboratory, Michigan State University, East Lansing, MI, (8)Chemical Engineering and Materials Science, DOE Great Lakes Bioenergy Research Center, Michigan State University, Lansing, MI, (9)Department of Chemical Engineering and Materials Science, Michigan State University, DOE Great Lakes Bioenergy Research Center, Lansing, MI
4:00 PM
Protein stability engineering by structure-guided chimeragenesis
Thijs Kaper1, Igor Nikolaev2, Sergio Sunux1, Amy Liu1, Rick Bott1, NilsEgil Mikkelsen3, Saeid Karkehabadi4, Dr. Henrik Hansson3, Mikael Gudmundsson3 and Dr. Mats Sandgren3, (1)DuPont Industrial Biosciences, Palo Alto, CA, (2)DuPont Industrial Biosciences, Leiden, Netherlands, (3)Department of Chemistry and Biotechnology, Swedish University of Agricultural Sciences, Uppsala, Sweden, (4)Department of Chemistry and Biotechnology, Swedish Agricultural University, Uppsala, Sweden
Thijs Kaper1, Igor Nikolaev2, Sergio Sunux1, Amy Liu1, Rick Bott1, NilsEgil Mikkelsen3, Saeid Karkehabadi4, Dr. Henrik Hansson3, Mikael Gudmundsson3 and Dr. Mats Sandgren3, (1)DuPont Industrial Biosciences, Palo Alto, CA, (2)DuPont Industrial Biosciences, Leiden, Netherlands, (3)Department of Chemistry and Biotechnology, Swedish University of Agricultural Sciences, Uppsala, Sweden, (4)Department of Chemistry and Biotechnology, Swedish Agricultural University, Uppsala, Sweden
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