Session 5: Teaching old dogs new tricks: Novel catalytic reactions mediated by P450 enzymes
Monday, July 25, 2016: 8:00 AM-11:30 AM
Grand Couteau, 5th Fl (Sheraton New Orleans)
Ellen Neidle - University of Georgia and Rudi Fasan - University of Rochester
The cytochrome P450 enzyme superfamily exhibits remarkable versatility in function, substrate range, and catalytic breadth. The wide variety of regiospecific and stereospecific oxidation reactions that can be catalyzed under mild conditions makes these enzymes ideal for biotechnology applications. However, the exciting potential of exploiting cytochrome P450 enzymes for industrial purposes has yet to be fully realized. This session addresses novel approaches for the modification, design, and characterization of enzymes belonging to this diverse superfamily.

8:00 AM
Developing biocatalysts for the production of nitroaromatics
Yousong Ding1, Ran Zuo1, Yi Zhang1, Jose Huguet-Tapia2, Mishal Mehta1, Evelina Dedic1, Steven Bruner3 and Rosemary Loria2, (1)Medicinal Chemistry, University of Florida, Gainesville, FL, (2)Plant Pathology, University of Florida, Gainesville, FL, (3)Chemistry, University of Florida, Gainesville, FL
8:30 AM
Engineered P450-based biocatalysts for C(sp3)−H amination reactions
Rudi Fasan, Department of Chemistry, University of Rochester, Rochester, NY
9:00 AM
Novel enzymes for lignin degradation generated with an easy chromosomal gene amplification method
Ellen Neidle, Melissa Tumen-Velasquez and Alaa Ahmed, Microbiology Department, University of Georgia, Athens, GA
9:30 AM
Break Sponsored by YSI Life Sciences, Grand Ballroom, 5th Fl
10:00 AM
New recipes for biocatalysis: expanding the cytochrome P450 reaction landscape for non-natural chemistry
Eric Brustad, Department of Chemistry, University of North Carolina at Chapel Hill, Durham, NC
10:30 AM
Applications of enzyme cascades in organic synthesis
Sabine Flitsch, Chemistry, The University of Manchester, Manchester, United Kingdom
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