Session 4: Molecular mechanisms of bioactive fungal natural products biosynthesis
Monday, July 25, 2016: 8:00 AM-11:30 AM
Bayside A, 4th Fl (Sheraton New Orleans)
Zhiqiang An - Brown Foundation Institute of Molecular Medicine and Joan W. Bennett - Rutgers University
In spite of the success of natural products as a chemical resource for drug leads, during the last two decades the drug discovery industry has tended to deemphasize natural products drug discovery. This is partly due to the fact that industrial discovery of bioactive fungal metabolites is a complex, expensive, integrated but somewhat empirical process. Advances in fungal genomics have demonstrated that natural products biosynthetic pathways are vastly more diverse and experimentally tractable than previously imagined. This session will focus on elucidation of the molecular mechanisms of fungal natural products biosynthesis and how such knowledge will speed up rational access of the vast fungal natural products repertoire uncovered by genomics for drug discovery.
8:00 AM
Esterification and dipeptide offsite uploading are mediated by fungal nonribosomal peptide synthetases
Wen-Bing Yin, Dr. Aili Fan, Dr. Wei Li, Dr. Peng Zhang and Dr. Zhiguo Liu, Institute of Microbiology, Chinese Academy of Sciences, State Key Laboratory of Mycology, Chaoyang District Beijing, China
8:30 AM
Exploiting the inconspicuous xylariaceous fungi as prolific sources for the discovery of new natural products
Eric Kuhnert, Microbial Drugs, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany
9:00 AM
Biosynthesis of bioactive molecules in the medicinal insect pathogenic fungi
Chengshu Wang, Mr. Peng Feng, Dr. Yongliang Xia and Mr. Feifei Luo, Institute of Plant physiology and Ecology, Shanghai Institutes for Biological Sciences, CAS, Shanghai, China
9:30 AM
Break Sponsored by YSI Life Sciences, Grand Ballroom, 5th Fl
10:00 AM
Large scale discovery and deorphanization of natural products using fungal artificial chromosomes and untargeted metabolomics (FAC-MS)
Nancy Keller1, Kenneth Clevenger2, Jin-Woo Bok1, Rosa Ye3, Galen Miley2, Thomas Velk1, Cynthia Chen3, KaHoua Yang4, Peng Gao5, Matthew Lamprecht3, Paul Thomas5, Md Islam3, Chengcang Wu3 and Neil L. Kelleher2, (1)Medical Microbiology and Immunology, University of Wisconsin, Madison, WI, (2)Chemistry, Northwestern University, Evanston, IL, (3)Intact Genomics, Inc., St Louis, MO, (4)Bacteriology, University of Wisconsin, Madison, WI, (5)Proteomics Center of Excellence, Northwestern Univeristy, Evanston, IL
10:30 AM
Novel Chemistry from Thermophilic Fungi
Xue-Mei Niu, State Key Laboratory for Conservation and Utilization of Bio-Resources, Yunnan University, Kunming, China
11:00 AM
The pneumocandin family of antifungal drugs – Update on biodiversity and biosynthesis
Gerald F. Bills, University of Texas Health Science Center at Houston, The Brown Foundation Institute of Molecular Medicine, Houston, TX
See more of: Presentations