Session 18: Genomics-guided NP discovery and engineering in bacteria
Tuesday, July 26, 2016: 1:00 PM-4:30 PM
Bayside A, 4th Fl (Sheraton New Orleans)
Jeffrey Kim - Radiant Genomics and Nathan A. Magarvey - McMaster University
Genomics continues to play an increasingly important role in the discovery of natural products.Specifically, recent advances in next-generation sequencing, data analysis, genetic engineering, and analytical chemistry now allow for the routine discovery of previously-inaccessible natural product chemical diversity in our environment. Together, these technologies open enticing possibilities for both industrial and academic research. For industrial applications, these developments allow for targeted natural product discovery and production, while also enabling rational process engineering for cost optimization. For academic applications, these advances will enable us to rationally perturb and understand the role that natural products play in their native environment. This session will focus on recent progress in each discipline, highlighting both academic and industrial applications of genomics in natural product research.
1:30 PM
A new genome mining tool redefines the lasso peptide biosynthetic landscape
Douglas Mitchell, Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL
2:30 PM
Break, Grand Ballroom 5th Fl
3:00 PM
Mechanistic insights and engineering of Paclitaxel biosynthetic pathway
Steven Edgar1, Dr. Kangjian Qiao2, Prof. Kang Zhou3 and Greg Stephanopoulos2, (1)Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, (2)Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, (3)Chemical Engineering, National University of Singapore, Singapore, Singapore
3:30 PM
Biosynthesis of antimycin-type depsipeptides
Joyce Liu, UC Berkeley, Berkeley, CA and Wenjun Zhang, Chemical and Biomolecular Engineering, UC Berkeley, Berkeley, CA
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