Session 17: Adaptive evolution and genome stability in strain development
Tuesday, July 26, 2016: 1:00 PM-4:30 PM
Bayside B/C, 4th Fl (Sheraton New Orleans)
Noel Fong - Nucelis, Inc. and Katy C. Kao - Texas A&M
Adaptive evolution is a powerful tool harnessing the cell's abilities to optimize its survival in a new environment, complementing rational approaches in strain development. This session will focus on recent advances in inverse strain engineering using adaptive laboratory evolution combined with high-throughput technologies and the development of novel tools.  In addition, strategies will be presented on preventing adaptive evolution during long-term fermentations to improve strain stability.
1:00 PM
Directed and adaptive evolution approaches for strain engineering
Hal Alper, Department of Chemical Engineering, The University of Texas at Austin, Austin, TX
1:30 PM
Adaptive laboratory evolution of product-tolerant hosts for biobased chemical production
Rebecca Lennen, Kristian Jensen, Sailesh Malla, Elsayed Mohamed, Ksenia Chekina, Morten Sommer, Dr. Adam Feist, Alex Nielsen and Markus Herrgard, The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Hørsholm, Denmark
2:00 PM
Leveraging adaptive evolution to diagnose and combat genomic instability in Acinetobacter baylyi ADP1
Brian Renda1, Gabriel Suarez1, Dacia Leon1, Aurko Dasgupta1, Cindy Chan1, Dr. Kristin Parent2 and Dr. Jeffrey Barrick1, (1)Molecular Bioscience, University of Texas at Austin, Austin, TX, (2)Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI
2:30 PM
Break, Grand Ballroom 5th Fl
3:00 PM
Automated genome engineering of yeast cells using a Biological Foundry
Tong Si, Carl. R Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL and Zhao Huimin, Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL
3:30 PM
An automated adaptive laboratory evolution platform for industrial biotechnology
Troy Sandberg, Dr. Adam Feist and Prof. Bernhard Palsson, Bioengineering, UCSD, La Jolla, CA
4:00 PM
Mechanisms underlying the adaptation of Candida glabrata to environmental stressors
Mian Huang, Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX and Katy C. Kao, Texas A&M, College Station, TX
4:30 PM
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