Session 22: Process controls & analytical technologies for fermentation
Wednesday, July 27, 2016: 8:00 AM-11:30 AM
Grand Chenier, 5th Fl (Sheraton New Orleans)
Mark Berge - MedImmune and Frank Agbogbo - Cytovance Biologics
Understanding a fermentation process is fundamental to the ability of providing avenues for productivity improvement.  Either through real-time monitoring of fermentations, methods to better characterize a design space, or ways to develop research avenues, analytics are a critical tool in any scientist’s repertoire.  The ability to measure metabolites, substrates, and product quality has been steadily improving through the years and with recent increases in computational power, a new generation of analytical tools have begun to surface for a scientist’s routine use.  Examples of how these analytical technologies have been used to improve process control for fermentation processes will be presented in this session.
8:00 AM
Analytical methods to support recombinant microbial fermentation process development
Rachel Chang, Analytical Development, Cytovance Biologics, Oklahoma, OK, Renija George, Fermentation Development, Cytovance Biologics, Oklahoma, OK and Frank Agbogbo, Director of Fermentation, Cytovance Biologics, Oklahoma City, OK
9:00 AM
Recent advances in automated nutrient feeding for fermentors - using MRI to monitor and control metabolic activity
Greg Emmerson1, Sam Watts1 and George Barringer2, (1)Stratophase Ltd, Romsey, United Kingdom, (2)Stratophase Ltd (USA), W Groton, MA
9:30 AM
Break, Grand Ballroom Foyer 5th Fl
10:00 AM
Real-time monitoring and analysis of biological cultures using inline intelligent spectroscopy and real-time intelligent analytics.
Joel Sirois, Chemical engineering and Biotechnological engineering, Universite de Sherbrooke, Sherbrooke, QC, Canada, Dr. Guillaume Cardin-Bernier, BioIntelligence Technologies inc., Sherbrooke, QC, Canada and Emmanuel Bizier, CMC Biologics, Søborg, Denmark
10:30 AM
Evaluation of In-line optical density sensor technology in reducing fermentation process variability
John Davis, Principal Scientist, Cytovance Biologics, Oklahoma City, OK and Frank Agbogbo, Director of Fermentation, Cytovance Biologics, Oklahoma City, OK
11:00 AM
Real-time bioprocess control applications utilizing in situ Raman spectroscopy for process optimization, reduced batch-to-batch variability, improved quality, and advanced process control
Sean Gilliam1, Maryann E. Cuellar1, Juan Aon2, Jianxin Sun2, Alexander Pitters3, Pat Wiegand1, David Strachan1, Herve Lucas3, Bruno Lenain3 and Ian Lewis1, (1)Kaiser Optical Systems Inc., Ann Arbor, MI, (2)GlaxoSmithKline, King of Prussa, PA, (3)Kaiser Optical Systems Inc. SARL, Ecully, France
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