Session 2: Disposable technologies for high throughput fermentation
Monday, July 25, 2016: 8:00 AM-11:30 AM
Grand Chenier, 5th Fl (Sheraton New Orleans)
Steven Doig - Dupont and Bryce Causey - New England Biolabs
Markets in our industry today are very competitive. Whether your industry is biologics, pharmaceuticals or commodity chemicals the company with the best strain, the novel product, or the most efficient process will reap the rewards. Therefore, during process development it is imperative to be able to rapidly screen many variables. It is well known in our industry that screening in flasks does not translate well to the fermenter which makes it difficult to know that the clone or growth medium selected is the optimum for production. Furthermore, screening many process conditions using traditional glass bioreactors is very time consuming and labor intensive. High throughput cell culture/fermentation technologies are increasingly being utilized to screen for optimum strains and analyze many process conditions in much less time than is required for traditional glass vessel fermenters. This session will demonstrate how the use of disposable, high throughput fermentation technology can facilitate clone screening for the best production clone and screen many fermentation conditions to find the most robust process.
8:00 AM
Micro and mini bioreactors for microbial strain and process development: experiences with the ambr 15 fermentation and ambr 250 systems
Greg Keil1, Jason Saunders1, John Betts2, Kevin McHugh2 and Barney Zoro2, (1)Merck Research Laboratories, Kenilworth, NJ, (2)Sartorius Stedim Biotech Group, Royston, United Kingdom
9:00 AM
Purpose built 6L-300L single-use fermentors enable high throughput fermentation
Jason Brown and Nephi Jones, Research & Development, Thermo Fisher Scientific, Logan, UT
9:30 AM
Break Sponsored by YSI Life Sciences, Grand Ballroom, 5th Fl
10:00 AM
High throughput evaluation of sugar beet vinasse for industrial enzyme production
Gary Lye, Max Cárdenas-Fernández and Nurashikin Binti Suhaili, Department of Biochemical Engineering,, University College London, London, United Kingdom
11:00 AM
A Polymer based release system for fed-batch screening
Kristina Bruellhoff, PS Biotech GmbH, Aachen, Germany
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