2016 SIMB Annual Meeting and Exhibition

Markets in our industry today are very competitive. Whether your industry is biologics, pharmaceuticals or commodity chemicals the company with the best strain, the novel product, or the most efficient process will reap the rewards. Therefore, during process development it is imperative to be able to rapidly screen many variables. It is well known in our industry that screening in flasks does not translate well to the fermenter which makes it difficult to know that the clone or growth medium selected is the optimum for production. Furthermore, screening many process conditions using traditional glass bioreactors is very time consuming and labor intensive. High throughput cell culture/fermentation technologies are increasingly being utilized to screen for optimum strains and analyze many process conditions in much less time than is required for traditional glass vessel fermenters. This session will demonstrate how the use of disposable, high throughput fermentation technology can facilitate clone screening for the best production clone and screen many fermentation conditions to find the most robust process.