Session 12: Novel Tools for Natural Product Discovery
Tuesday, July 22, 2014: 8:30 AM-11:30 AM
Regency Ballroom A, Second Floor (St. Louis Hyatt Regency at the Arch)
Convener:
Huimin Zhao - University of Illinois at Urbana-Champaign, Urbana, IL
Natural products have been and continue to be the source and inspiration for small molecule drugs. Recent advances in genomics, bioinformatics, and synthetic biology have rekindled interest in natural product discovery. This session will showcase the top-down and bottom-up approaches for discovering natural products including but not limited to diverse sampling and innovative culturing and screening approaches, as well as genomics-driven discovery and genetic manipulation techniques for both native and heterologous expression.

8:30 AM
S64
Discovery of Novel Phosphonate Natural Products and Their Biosynthetic Pathways by Large-Scale Genome Mining
Kou-San Ju1, Jiangtao Gao1, James Doroghazi1, Steven Li1, Emily Metzger1, John Fudala1, Joleen Su1, Junkai Zhang1, Jaeheon Lee1, Joel Cioni1, Brad Evans1, Ryuichi Hirota1, David Labeda2, Wilfred van der Donk3 and William Metcalf4, (1)Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, (2)ARS (NRRL) Culture Collection, USDA/Agricultural Research Service, Peoria, IL, (3)Chemistry, Howard Hughes Medical Institute and the University of Illinois at Urbana-Champaign, Urbana, IL, (4)Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL
9:00 AM
S65
Genome-guided strain improvement for natural products biosynthesis
Nigel Mouncey, Babu Raman, Shreedharan Sriram, Shrinivasrao Mane, Nadaraj Palaniappan and Clive Evans, Dow AgroSciences LLC, Indianapolis, IN
FINAL_2014_07_22_Genome_Guided_Natural_Products.pdf
10:00 AM
S66
Harnessing molecular networking for high throughput screening for marine specialized metabolites
Tal Luzzatto Knaan1, Neha Garg1, Yao Peng1, Evgenia Glukhov2, William H. Gerwick2 and Pieter C. Dorrestein1, (1)Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, (2)Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA
10:30 AM
S67
Towards Biotechnology 2.0: synthetic biology of bioactive molecules
Eriko Takano, Faculty of Life Sciences, Manchester Institute of Biotechnology, University of Manchester, Manchester, England
11:00 AM
S68
A Deep Dive into Aquatic Microbial Consortia for Drug Discovery
Guy T. Carter, Biosortia Pharmaceuticals, Dublin, OH
Carter_SIMB_July2014.pdf
See more of: Invited Oral Papers
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