Session 6: Metabolic Engineering for Renewable Chemical Production
Monday, July 21, 2014: 1:00 PM-4:30 PM
Regency Ballroom D, Second Floor (St. Louis Hyatt Regency at the Arch)
David R. Nielsen - Arizona State University, Tempe, AZ and Andreas Schirmer - REG Life Sciences, LLC, South San Francisco, CA
Industrial chemicals are the building blocks for a multitude of materials and polymers. Fine chemicals and pharmaceutical precursors, meanwhile, are used as building blocks to produce many important specialty products and drugs. Together, such products are entwined within our daily lives. At present, however, nearly all of these products are produced almost exclusively from petrochemical feedstocks. The use of microorganisms to convert biobased feedstocks to these same products is emerging as a transformational technology for sustainable chemical production. Rapid advances in metabolic engineering, systems biology, and synthetic biology have contributed to recent success in this field. This session will cover development of microorganisms and fermentation processes for the production of both fine and commodity chemicals from sugars or other biobased feedstocks, and the approaches used to develop them. The specific emphasis will be on the engineering of novel pathways and microbes for the production of non-natural products and/or non-traditional fermentation products. Various stages of the research workflow will be covered, from proof-of-concept research to commercial success stories.

1:00 PM
Metabolic engineering for products derived from malonyl-CoA
Tanya Warnecke Lipscomb, OPXBIO, Boulder, CO
1:30 PM
Re-inventing central carbon metabolism in Saccharomyces cerevisiae for high-volume production of isoprenoids
Annie E. Tsong, Kristy Hawkins, Yoseph Tsegaye, Adam Meadows, Lauren Pickens, Anna Tai, Tina Mahatdejkul-Meadows, Eugene Antipov, Madhukar Dasika, Lan Xu, Lily Chao, Savita Ganesan, Jefferson Lai, Patrick Westfall and Timothy Gardner, Biology, Amyris Inc., Emeryville, CA
2:00 PM
Scalable production of mechanically tunable block polymers from sugar
Kechun Zhang, Dept. Chemical Engineering & Materials Science, University of Minnesota, Minneapolis, MN
3:00 PM
Engineering a metabolic platform to produce a rich portfolio of renewable chemicals
Steve del Cardayre, REG Life Sciences LLC, South San Francisco, CA and Andreas Schirmer, Director, Pathway Engineering, REG Life Sciences, LLC, South San Francisco, CA
3:30 PM
Acetylation: The Key to Increased Xanthophyll Titers in Yarrowia lipolytica
Christopher M. Farrell, Maria Mayorga, Lisa Laprade, Peter Houston, Daniel Grenfell-Lee and Joshua Trueheart, DSM Nutritional Products, Lexington, MA
4:00 PM
Development of a generalized platform to produce biochemicals from lignin
Tae Seok Moon and William R. Henson, Energy, Environmental and Chemical Engineering, Washington University in St. Louis, St. Louis, MO
See more of: Invited Oral Papers