Session 14: Strain Selection for Successful Fermentation Scale-Up
Tuesday, July 22, 2014: 1:00 PM-4:30 PM
Regency Ballroom A, Second Floor (St. Louis Hyatt Regency at the Arch)
Conveners:
Kirsten R. Benjamin - Amyris Inc., Emeryville, CA and Amoolya Singh - Amyris Inc., Emeryville, CA
A crucial challenge in industrial microbiology is how to choose the best manufacturing strains based on phenotypic characterizations of strains grown in flasks or plates. This session will cover approaches to micro-scale assay development, selection of strains to test and scale-up, how many replicates need to be tested and at what scale, when to discard candidates, and how to statistically monitor strain selection processes.

1:00 PM
S75
Microscale assay development for advanced microbial phenotyping in higher throughput
Andreas Radek, Simon Unthan, Marco Oldiges and Stephan Noack, Institute of Bio- and Geosciences, IBG-1: Biotechnology, Systems Biotechnology, Research Center Juelich, Juelich, Germany
1:30 PM
S76
Strain screening for isoprenoid production in bioreactors: balancing throughput and production scale constraints
B. Oud, Amyris inc., Emeryville, CA
2:00 PM
S77
Design-build-test-analyze workflow for strain optimization
Irina Borodina, Kanchana R Kildegaard, Niels B Jensen, Svetlana Sherstyk, Jérôme Maury, Jochen Forster, Markus Herrgård and Jens Nielsen, The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Hørsholm, Denmark
3:00 PM
S78
Predicting Scale-Up of Microbial Production Performance from 96-well plates to Benchtop Fermentors
Amoolya Singh, Amyris Inc., Emeryville, CA
3:30 PM
S79
Hide and seek: improved microbial strains vs. researchers
Tommaso Liccioli, School of Agriculture, Food & Wine, The University of Adelaide, Glen Osmond, Australia
Tommaso Liccioli - SIMB 2014.pdf
See more of: Invited Oral Papers
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