S32: MbtH-like proteins in nonribosomal peptide biosynthesis

Nonribosomal peptides are secondary metabolites of clinical relevance that are produced by multi-modular enzymatic assembly-lines termed nonribosomal peptide synthetases. Each module contains three core domains, an adenyation, a thiolation, and a condensation domain responsible for activation, loading, and growing of the peptide chain, respectively. MbtH-like proteins have been found to play an important role in production and activity of adenylation enzymes. This presentation will focus on the potential of MbtH-like protein in generating novel nonribosomal peptides.