Natural Products - Bioengineering in drug discovery

Tuesday, August 14, 2012: 8:30 AM-11:30 AM
Jefferson West, Concourse Level (Washington Hilton)
Huimin Zhao

8:30 AM
Genome mining of polyketides and nonribosomal peptides in Aspergillus nidulans
Clay C. C. Wang, Pharmacology and Pharmaceutical Sciences, Univ. of Southern California, Los Angeles, CA
9:00 AM
Unexpected role of a ketosynthase in antibiotic biosynthesis
Tom Bretschneider1, Georg Zocher2, Michelle Unger1, Kirstin Scherlach1, Thilo Stehle3 and Christian Hertweck1, (1)Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany, (2)Interfaculty Institute of Biochemistry, Eberhard Karls University Tübingen, Tübingen, Germany, (3)Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN
9:30 AM
10:00 AM
Discovery of novel natural products by refactoring cryptic pathways
Huimin Zhao, Zengyi Shao and Yunzi Luo, Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL
10:30 AM
Mapping unchartered territory – sesquiterpenoid discovery in mushrooms
Maureen B. Quin, Grayson T. Wawrzyn, Fernando Lopez-Gallego and Claudia Schmidt-Dannert, Biochemistry, Molecular Biology and Biophysics, University of Minnesota, St. Paul, MN
11:00 AM
Engineering C-H oxidation chemistry in bacteria
Marjan De Mey1, Chin Giaw Lim2, Vikram G. Yadav2, Ajikumar Parayil1 and Gregory Stephanopoulos2, (1)Manus Biosynthesis, Cambridge, MA, (2)Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA
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