Paper: Anticancer activity of polysaccharide from <i>Boletus vermiculosoides</i> against lung cancer cell line (Annual Meeting and Exhibition 2010 (August 1-5, 2010))

Monday, August 2, 2010

Pacific Concourse (Hyatt Regency San Francisco)

Sehanat Prasongsuk¹, Wissarut Kitpipit¹, Orawan Satayalai², Pongtharin Lotrakul¹, Aniwat Chalermpongse¹, Douglas E. Eveleigh³ and Hunsa Punnapayak¹, (1)Plant Biomass Utilization Research Unit, Department of Botany, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand, (2)Department of Biology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand, (3)Department of Biochemistry and Microbiology, Rutgers University, School of Environmental and Biological Sciences, New Brunswick, NJ

The objective of this research was to assess the anticancer activity of polysaccharide extracted from a tropical mushroom, Boletus vermiculosoides, against lung cancer cell line. B. vermiculosoides basidiocarps were collected from a forest in north-eastern Thailand and identified using morphological examination. Its polysaccharide was extracted using hot water extraction and polysaccharide content was determined using anthrone test method. The crude extract of B. vermiculosoides contained 1.77 mg/ml polysaccharide. This polysaccharide exhibited potent inhibitory activity against lung cancer cell line (95.56% inhibition) with 50% cell inhibition (IC₅₀) at 0.08 mg/ml. At IC₅₀, the polysaccharide affected hepatic cell line with 9.92% inhibition. This research suggested the potential use of polysaccharide from B. vermiculosoides for cancer treatment.

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