Tuesday, July 28, 2009: 8:30 AM-11:30 AM
Pier 4 (Westin Harbour Castle Hotel)
Session 13: Bisoynthetic enzymes in three dimensions
Chair:Sheryl Tsai
8:30 AMStructure and mechanism of nonribosomal peptide biosynthetic enzymes
Steven D. Bruner
9:00 AMFormation of the unusual double bonds in curacin A by its polyketide synthase
Janet L. Smith, David L. Akey, Jennifer J. Gehret, Liangcai Gu, David H. Sherman, Bo Wang, Kristina Håkansson, Lena G. Gerwick, William H. Gerwick
9:30 AMStructural and mechanistic analyses of chain elongation and transfer in a polyketide synthase module
Shiven Kapur, Chaitan Khosla
10:00 AMcoffee break
10:30 AMStructural and Mechanistic Understanding of Type I Iterative Polyketide Synthases
Craig A. Townsend
11:00 AMCyclizations of Type II Aromatic Polyketide Synthase
Sheryl Tsai, Brian Ames, Tyler Korman, Ming Lee

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