Genome mining for secondary metabolism of Chondromyces crocatus KYC2823

Chondromyces crocatus is a member of myxobacteria, which exhibits multicellular development and complex fruiting bodies with social behavior. A significant property of C. crocatus is the production of diverse bioactive compounds. C. crocatus strain KYC2823 was isolated from soil sampled in South Korea and was chosen for genome sequencing and mining. GS FLX Titanium and Illumina Genome Analyzer were employed to determine the genome sequence of KYC2823. The genome consists of a single circular chromosome of 11.4 Mb with 68.7% G + C content. The genome of KYC2823 contains an array of genes and gene clusters involved in secondary metabolism, which may be responsible for production of the bioactive compounds. The genome was compared with the genomes of other myxobacteria to further explore candidate genes involved in biosynthesis of secondary metabolites. [Financial support from the Global Frontier Intelligent Synthetic Biology Center (NRF-2012M3A6A8053632) and NRF-2011-0017670]