P104 Production of diverse, highly reduced compounds using polyketide synthases
Monday, January 12, 2015
California Ballroom C and Santa Fe Room
Ryan Phelan1, Peter Kelly1, Sean Poust2, Ben Adler3, Jesus Barajas4, Samuel Deutsch1, Shiou-Chuan Tsai5, Leonard Katz6 and Jay Keasling7, (1)Lawrence Berkeley National Laboratory, Joint BioEnergy Institute, Berkeley, CA, (2)Department of Chemical and Biomolecular Engineering, University of California, Berkeley, Emeryville, CA, (3)University of California, Berkeley, CA, (4)University of California, Irvine, Irvine, CA, (5)Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, (6)Joint BioEnergy Institute, Emeryville, CA, (7)Fuels Synthesis - Synthetic Biology, Joint BioEnergy Institute, Emeryville, CA
Recent concerns about the supply and cost of petroleum based fuels and commodity chemicals have sparked an interest in identifying alternate routes to desirable compounds. To address current needs we have focused on using polyketide synthases (PKS) to produce diverse, highly reduced hydrocarbons that possess unique terminal functional groups. While establishing a biological route to numerous chemicals by varying the starter unit or chain termination mechanism we have generated a library of chimeric PKSs which was investigated for functionality using a state-of-the-art tandemLC-MS/MS method. This study aims to demonstrate the flexibility of modular catalysis; combined with investigations regarding novel termination modes, we aim to provide a sustainable route to numerous, functionally differing renewable chemicals.
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