P12
Chemical Biology for modulators targeting cancer microenvironment and cell membrane signaling
Monday, January 12, 2015
California Ballroom C and Santa Fe Room
Exploration of novel small molecules from natural sources such as microbial metabolites, medicinal plants, and marine invertebrates has contributed to the dicovery of not only lead molecules for drugs but also research tools on chemical biology. Chemial biology based on forward/reverse chemical genetics accerelates drug development and the functional analysis of genes and proteins. We have discovered several novel bioactive metabolites by both in vivo cell-based phenotypic screenings and in vitro target-oriented screenings, and investigated their modes of action using a chemical genetics or a chemical genomics approach.1)
In this conference, we present chemical genetics approaches for microbial metabolites targeting cancer microenvironmetnt and cell membrane signaling, as well as development of 5-SOxT probe for chemical tagging of a drug target using 5-sulfonyl tetrazole. 2)
1) URL:http://www.pharm.kyoto-u.ac.jp/sc-molsci/
2) a) Yoshimura, A. et al. J. Org. Chem. 79, 6858 (2014); b) Sugiyama, R. et al. J. Am. Chem. Soc. 136, 5209 (2014); c) Kishimoto, S. et al. Org. Lett. in press (2014); d) Ishikawa, F. et al. Bioorg. Med. Chem. Lett. 24, 865 (2014); e) Ostuki, S. et al. Bioorg. Med. Chem. Lett. 23, 1608 (2013).