Gasification is a thermochemical process that converts a wide range of carbonaceous resources mainly into syngas, a gaseous mixture that contains H₂, CO, CO₂, CH₄ and light hydrocarbons, and can be applied in the generation of heat, power, and fine chemicals. Such versatility of the gasification technology, both in terms of feeding and applications, makes it an interesting thermoconversion option for underused feedstocks like sugarcane bagasse. Sugarcane bagasse, an abundant agricultural residue derived from the sugar-alcohol industry, is usually burned in boilers for power generation, a practice that results in low yields and ash production. Despite some experimental initiatives on sugarcane bagasse gasification, none of them focuses on obtaining high-quality syngas for higher added-value applications. Due to this necessity, this work aims at studying via simulation the operating conditions that lead to a high calorific power syngas in a sugarcane bagasse gasification process that takes place in a circulating fluidized bed. To achieve this goal, a simulation model based on Gibbs free energy minimization was proposed in the Aspen Plus^TM software, and the effects of gasification temperature, pressure, steam-to-biomass ratio, and biomass moisture content on H₂/CO ratio, syngas lower heating value and energy demands were assessed in a 2⁴ factorial design. The results have shown that sugarcane bagasse gasification is a potential upstream process for chemicals production, contributing as an alternative not only for the usual bagasse processing methods but also for the development of current bagasse gasification activities.