Rapid commercialization using an integrated approach to bioprocess development

Genomatica has developed a complete, commercial-scale bioprocess for production of 1,4-butanediol (BDO) directly from carbohydrates, which has been producing thousands of tons since 2012.  This presentation will discuss the integrated approach inherent to Genomatica’s biotechnology platform that made this faster and less expensive than traditional bioprocess development and scale up.  A key differentiator of this platform includes an emphasis on modeling and techno-economic analysis from the very start; using this information to guide decisions on organism, fermentation, and downstream process design. Combining this integrated approach with real-world commercial expertise enabled highly-reliable and predictable scale-up and scale-down results across multiple orders of magnitude.