Redesigning Microorganisms and Bioprocesses for Biofuel Production
Tuesday, April 29, 2014
Exhibit/Poster Hall, lower level (Hilton Clearwater Beach)
Carine Bideaux1, S. Alfenore1, Jean-Louis Uribelarrea1, C. Molina-Jouve1, J.-M. Nicaud2, Elke Nevoigt3 and Stephane E. Guillouet1, (1)Laboratoire d'Ingénierie des Systèmes Biologiques et des Procédés (LISBP), Insitut National des Sciences Appliquées, Toulouse, France, (2)Micalis, CNRS, France, (3)School of Engineering and Science, Jacobs University gGmbH, Bremen, Germany
The aim of our contribution is to illustrate how systemic microbiological analysis from macroscopic to molecular levels taking into consideration fermentation consideration is an efficient way to develop innovative and efficient bioprocess for microbial production of chemical molecules from renewable carbohydrate resources.

Our projects deal with major identified bottlenecks such as the elaboration of strategies where microbial, metabolic and process engineerings are associated to improve the cost-effectiveness of microbial production.

We will describe experiments and modelling (kinetic and metabolic flux models) that allow enhancement of chemical production. The main results, achieving highly competitive processes compared to performances reported in the literature, will be reported such as:

● the improvement of the conversion yield of sugars into biofuel molecules by minimizing by-product production with Saccharomyces cerevisiae and Yarrowia lipolytica while keeping, respectively, intensive ethanol and lipid production

● the modulation of targeted biolipids profile through process and metabolic engineering