Computational enzyme design: a tool for rapidly designing new enzymatic activities
Alexandre Zanghellini, Arzeda Corporation, Seattle, WA

Initial- and processive-cut products from cellobiohydrolase-catalyzed hydrolysis of cellulose reveal rate-limiting steps and role of companion enzymes
Jerome Fox, Seth E. Levine, Douglas S. Clark and Harvey Blanch, Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, CA

Studies of synergism between two Thermobifida fusca cellulases, Cel48A and Cel9A, via empirical modeling and site directed mutagenesis
Maxim Kostylev¹, Mo Chen², M.E. Himmel³, John W. Brady² and David Wilson¹, (1)Molecular Biology and Genetics, Cornell University, Ithaca, NY, (2)Department of Food Science, Cornell University, Ithaca, NY, (3)National Renewable Energy Laboratory, Golden, CO

Break/Exhibits open Napoleon Foyer, 3rd fl

Hydrogen deuterium exchange mass spectrometry-based enzyme dynamics analysis revealed rew structure determinants and mechanisms
Ugur Uzuner¹, Weibing Shi¹, Hong Guo², Susie Y. Dai³ and Joshua S. Yuan¹, (1)Department of Plant Pathology and Microbiology, Texas A&M University, College Station, TX, (2)Department of Biochemistry and Cell and Molecular Biology, University of Tennessee, Knoxville, TN, (3)Office of the Texas State Chemist, Texas A&M University, College Station, TX

Probing cellulase binding on crystalline cellulose surfaces using large-scale molecular dynamics simulations
Giovanni Bellesia, Theoretical Biology and Biophysics Group & Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, NM, Shishir P. Chundawat, Chemical Engineering and Materials Science, Michigan State University, Lansing, MI, Michael Crowley, Biosciences Center, National Renewable Energy Laboratory, Golden, CO, Gregg Beckham, National Bioenergy Center, National Renewable Energy Laboratory, Golden, CO, Bruce E. Dale, Chemical Engineering and Materials Science, DOE Great Lakes Bioenergy Research Center, Michigan State University, Lansing, MI and S. Gnanakaran, Theoretical Biology and Biophysics Group (T6), Los Alamos National Laboratory, Los Alamos, NM

Understanding fungal cellulases with molecular simulation
Gregg T. Beckham¹, Lintao Bu¹, Christina M. Payne², Courtney B. Taylor³, Deanne W. Sammond², Mark Nimlos², Clare McCabe³, Yuchun Lin⁴, Jhih-Wei Chu⁴, Clare J. Dibble¹, Mike E. Himmel² and Michael F. Crowley², (1)National Bioenergy Center, National Renewable Energy Laboratory, Golden, CO, (2)Biosciences Center, National Renewable Energy Laboratory, Golden, CO, (3)Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, (4)Department of Chemical Engineering, University of California Berkeley, Berkeley, CA