Microbial organisms are capable of producing a wide variety of molecules, which can be utilized as potential infrastructure compatible fuels and fuel precursors. These products include higher alcohols, ethers, esters, fatty acids, alkenes and alkanes. Understanding the basic elements of microbial conversion to hydrocarbon fuels and fuel precursors is the first step towards identifying a basis for future research directions in this field. Specifically, research presented here focuses on identifying biochemical synthesis pathways to higher alcohols, fatty acids, isoprenoids, and polyketides, which can be used in production of desired fuels such as jet, diesel and gasoline. Besides biochemical pathways identification, energy and mass balance evaluation and preliminary technoeconomic analyses is presented to provide a better understanding of the path to commercialization. Commercial production of such molecules is in preliminary stages with more research needed to understand the technical and economical impacts of the processes involved.