12-05: Integrated cellulsoic enzymes hydrolysis and fermentative all in one yeast biocornversion solution ready for biomass biorefineries

Biomass Bioconversion Solution: The DSM Way. Lignocellulosic biomass is the most abundant, least expensive renewable natural biological resource for the production of biobased products and bioenergy. It is important for the sustainable development of human civilization in 21st century.
For making the fermentable sugars from lignocellulosic biomass, a reduction in cellulase production cost, an improvement in cellulase performance, and an increase in sugar yields are all vital to reduce the processing costs of biorefineries. Improvements in specific cellulase activities for non-complexed cellulase mixtures can be implemented through cellulase engineering based on rational design or directed evolution for each cellulase component enzyme, as well as on the reconstitution of cellulase components. In this presentation, we will provide DSM's combined approach to cellulase research and developments along with focus on fermentative conversion of biomass derived hexoses and pentoses to ethanol by DSM AIO yeast. Cellulase and yeast improvement strategies based on directed evolution using screening on relevant substrates, screening for higher environmental tolerance based on activity screening approaches such as continuous culture using insoluble cellulosic substrates as a powerful selection tool for enriching beneficial cellulase mutants and better yeast species from large libraries. We will illustrate why and how thermostable cellulases and AIO Yeast are vital for economic delivery of bioproducts from cellulosic biomass using biochemical conversion approach and are also ready for deployment.