Filamentous fungi are emerging tools for the development of novel industrial bioprocesses. They are potentially important in the current search for environmentally friendly methods for waste disposal, detoxification, biofuels and chemical sources. Their morphological robustness and biochemical diversity confer them adequate characteristics for the high-stress, high-efficiency environments of an industrial process. However, it is precisely their characteristic filamentous morphology what makes them grow optimally on solid substrates, which are undesirable for most industrial fermentative processes. Liquid media composition regulates the size of mycelial clumps so that they remain small in size to increase mass transfer efficiency of nutrients. Our project focuses on the characterization of candidate proteins associated to the production of small granules by the model fungus Phanerochaete chrysosporium. The analysis method is SDS-PAGE electrophoresis for the detection of differentially expressed proteins on small-size granule induction medium and YMPG. These candidate proteins are to be subsequently identified using mass spectrometry. This characterization will provide important information for the creation of a platform that will enable the utilization of other filamentous fungi in the industrial production of important biochemicals.