Monday, May 5, 2008
9-38

Analysis of Fermentation Yield Coefficients from Autonomously Oscillating Open Yeast Cultures

J. Brian Robertson1, Chris C. Stowers2, Erik M. Boczko3, and Robert D. Tanner2. (1) Biological Sciences, Vanderbilt University, Nashville, TN 37232, (2) Chemical Engineering, Vanderbilt University, VU Station B 351604, Nashville, TN 37235, (3) Biomedical Informatics, Vanderbilt University, Nashville, TN 37232

Previous work has established the fact that self-sustained, autonomous oscillations exist within open yeast fermentations under a variety of operational parameters.  These oscillations may have a variety of impacts on substrate conversion to biomass and subsequent products.  This analysis assumes that the fermentor cell mass follows Monod kinetics.  Substrate and cell concentration data are fitted to mathematical models, permitting direct determination of fermentor yield.  The functional form of the fermentor yield is then analyzed under a variety of conditions.  Our analysis will elucidate the effects of these oscillations to potentially allow engineers to utilize these oscillations as a tool, rather than an obstruction.  The analysis could also be used to increase fermentor productivity in the biomass production and conversion industry.

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