Monday, May 5, 2008
6-33

Synergies of Integrating Enzyme Development and Substrate Understanding

Frank D. Haagensen, Harry Showmaker, David Milam, and Guillermo Coward-Kelly. BioFuels Research & Development, Novozymes North America, 77 Perry Chapel Church Road, Franklinton, NC 27525

Understanding processes for utilization of lignocellulosic substrates is a focus area for Novozymes North America, Inc. in order to generate valuable information for development of next generation cellulase enzymes and to provide our customers with an excellent level of technical support. A vast amount of research has been directed towards development of processes involving either combined or separate hydrolysis and fermentation, and lately various hybrid models have been proposed.

Development of new generation enzymes in combination with different pretreatments has an impact on the hydrolysis process. We will illustrate how mathematical models can be used as powerful tools in optimizing enzymatic hydrolysis and understanding substrate-enzyme interactions.