The production of high value commodity chemicals and bio-fuels by microorganisms relies on the identification of genes in mutants that allow for increased production. Having a reporter system that directly responds to the desired product would enable easier screens and/or selections of said mutants. However, most naturally occurring reporters, such as the Escherichia coli lactose promoter, are often sub-optimal as they may express at low levels, exhibit loose regulation, and respond only in natural conditions or environments. The goal of this work is therefore to develop a plasmid-based approach to couple the non-selectable phenotype of chemical production to a selectable phenotype. Using both computational and experimental techniques, we have developed a reporter system in which the selectable response conferred is dependent upon inducer concentration. Development of such plasmids for the improved production of organic acids is the focus of current activities.