Sunday, May 4, 2008 - 2:30 PM
2-02
The Development of TM242: A Novel Thermophilic Bacillus Capable of High Yield Ethanol Production
The parent strain of TM242, a Geobacillus sp., was chosen because of its ability to metabolise a wide range of biomass derived monomeric and oligomeric sugars. It is a facultative anaerobe capable of growth between 40-70oC and can ferment both hexose and pentose sugars to generate lactate, formate, acetate and relatively low amounts of ethanol as products. Newly developed metabolic engineering tools have been applied to this organism to alter the expression of key enzymes to produce TM242 in which acid production is essentially eliminated and ethanol is efficiently produced at yields approaching the theoretical maximum value. This presentation will outline the metabolic steps involved in the creation of TM242 and illustrate the performance benefits at each step.
Web Page: www.tmo-group.com
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