Session 26: Mechanism and application of NP tailoring biosynthesis
Wednesday, July 27, 2016: 8:30 AM-11:30 AM
Maurepas, 3rd Fl (Sheraton New Orleans)
Eung-Soo Kim - Inha University and David Sherman - University of Michigan
Novel natural product chemical scaffolds continue to provide access to important antimicrobial agents, immunomodulators, antitumor agents and other biologically active molecules. Natural product discovery is currently undergoing a renaissance due to a large extent on observations from pure genome and metagenome sequencing and powerful bioinformatic tools.  This new information is showing that only a fraction of the potential microbial secondary metabolites encoded by diverse bacteria and fungi have been discovered.  As genome mining has emerged and expanded, it is enabling new ways to increase access to and understanding of novel natural product biosynthetic systems. This session will encompass several fascinating topics on natural product biosynthetic pathways including new biochemical mechanisms, and diverse applications of key enzymes involved in tailoring of complex metabolites.
8:30 AM
Post-PKS tailoring mechanism of a disaccharide-containing polyene in pseudonocardia autotrophica
Eung-Soo Kim, Biological Engineering, Inha University, Incheon, Korea, The Republic of
9:00 AM
Mechanisms of cyclic ether formation in fungal natural product biosynthesis
Yi Tang, Chemical and Biomolecular Engineering, Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA
9:30 AM
Break, Grand Ballroom Foyer 5th Fl
10:00 AM
Chemical diversity of labdane-type bicyclic diterpene biosynthesis in Streptomyces
Haruo Ikeda, Kitasato Institute for Life Sciences, Kitasato University, Kanagawa, Japan
10:30 AM
Problems, progress and holy-grails in natural product sciences.
David H. Sherman, Life Sciences Institute & Associate Dean for Research and Graduate Education, University of Michigan, Ann Arbor, MI
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