Session 9: Natural products from higher fungi
Monday, July 25, 2016: 1:00 PM-4:30 PM
Grand Chenier, 5th Fl (Sheraton New Orleans)
Jonathan D. Walton - Michigan State University and Claudia Schmidt-Dannert - University of Minnesota
Fungi produce many ecologically and medically important natural products (NPs). Compared to the Ascomycetes (i.e., filamentous fungi), NPs from the “other” group of higher fungi, the Basidiomycetes, have been relatively less studied. Homology-based analysis of fungal genomes for known NP biosynthetic genes together with information on isolated NPs suggests that the secondary metabolomes of Basidiomycetes differ significantly from those of other prolific microbial NP producers such as filamentous fungi and actinomycetes. Mushroom-forming Basidiomyctes (agarics), for example, appear to have evolved a particularly rich repertoire of terpenoid and ribosomal peptide (RiPP) derived NPs that are often associated with specialized tissues and cell types lacking in filamentous fungi, such as lactiferous tissues and cystidia (storage cells). Furthermore, these fungi have unique lifestyles and ecological niches that have shaped their NP portfolios. This session will highlight recent significant advances in our understanding of the chemistry, biosynthesis, and ecology of NPs from higher fungi, with an emphasis on agarics.
1:00 PM
Accessing the unuque terpenoid natural products portfolios of Basidiomycota
Maureen B. Quin1, Claudia Schmidt-Dannert2, Stephen Michel2 and Christopher M. Flynn2, (1)Biochemistry, Molecular Biology and Biophysics, University of Minnesota, St. Paul, MN, (2)Dept. Biochemistry, Molecular Biology & Biophysics, University of Minnesota, St. Paul, MN
1:30 PM
Accessing silent chemistry in Fusarium graminearum
Donovon Adpressa1, Lanelle Connolly2, Xiao Chang2, Brett Pierce2, Kristina Smith2, Prof. Michael Freitag2 and Prof. Sandra Loesgen1, (1)Chemistry, Oregon State University, Corvallis, OR, (2)Biochemistry, Oregon State University, Corvallis, OR
2:00 PM
Chemical ecology of fungi
Peter Spiteller, Institut für Organische und Analytische Chemie, Universität Bremen, Bremen, Germany
2:30 PM
Break, Grand Ballroom 5th Fl
3:00 PM
Combinatorial biosynthesis of cyclic peptide natural products in Amanita mushrooms by a versatile macrocyclase
R Michael Sgambelluri, DOE Plant Research Lab and Department of Biochemistry, Michigan State University, East Lansing, MI and Jonathan D. Walton, Department of Energy Plant Research Lab, Michigan State University, East Lansing, MI
3:30 PM
Ribosomal peptide biosynthetic pathways widely conserved in filamentous fungi
Myco Umemura1, Dr. Nozomi Nagano2, Dr. Akira Yoshimi3, Ms. Ying Ye4, Dr. Atsushi Minami4, Prof. Keietsu Abe3, Dr. Kazuo Shin-ya2, Prof. Hideaki Oikawa4 and Dr. Masayuki Machida1, (1)National Institute of Advanced Industrial Science and Technology (AIST), Sapporo, Japan, (2)National Institute of Advanced Industrial Science and Technology (AIST), Tokyo, Japan, (3)Tohoku University, Sendai, Japan, (4)Hokkaido University, Sapporo, Japan
4:00 PM
Exploiting the secondary metabolome of tropical Basidiomycota
Frank Surup and Prof. Marc Stadler, Microbial Drugs, Helmholtz Centre for Infection Research, Braunschweig, Germany
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