2016 SIMB Annual Meeting and Exhibition

Successfully scaling fermentation processes often involves multiple stages and scale-up approaches to progress from an original invention in the laboratory to commercial production. Several scale-dependent process conditions can be modeled and tested, involving the design of scale-up or scale-down experiments. These tests are geared to assess the production organism’s sensitivity to anticipated commercial-scale conditions and are essential for ensuring predictable performance across scales without compromising on yield, productivity and product titer. This session will focus on the challenges of fermentation process scale up, the economic considerations, and applied scale down/scale-up strategies for novel bio-technologies.