Session 6: Scale without fail: Fermentation scale-up/scale down
Monday, July 25, 2016: 1:00 PM-4:30 PM
Bayside B/C, 4th Fl (Sheraton New Orleans)
Chandresh Thakker - Total New Energies USA, Inc. and Susanne Kleff - MBI International
Successfully scaling fermentation processes often involves multiple stages and scale-up approaches to progress from an original invention in the laboratory to commercial production. Several scale-dependent process conditions can be modeled and tested, involving the design of scale-up or scale-down experiments. These tests are geared to assess the production organism’s sensitivity to anticipated commercial-scale conditions and are essential for ensuring predictable performance across scales without compromising on yield, productivity and product titer. This session will focus on the challenges of fermentation process scale up, the economic considerations, and applied scale down/scale-up strategies for novel bio-technologies.
1:00 PM
Commercial scale up of gas fermentation
Michael Köpke and Sean Simpson, LanzaTech, Inc., Skokie, IL
2:00 PM
Accelerating process improvement through integrated bioprocessing
Nigel Mouncey, Bioengineering and Bioprocessing R&D, Dow AgroSciences LLC, Indianapolis, IN
2:30 PM
Break, Grand Ballroom 5th Fl
3:00 PM
From laboratory to wings: Biobased production of farnesene
Chandresh Thakker1, Paul Hill2, Joshua Leng2, Olivier Rolland1, Chi-Li Liu2, Doug Pitera2, Abhishek Murarka2, Elisa Porcel2 and Robert Dahl2, (1)Total New Energies USA, Inc., Emeryville, CA, (2)Amyris Inc., Emeryville, CA
3:30 PM
If you believe strain development is tough - try scale-up!
Andreas Worberg, Biotechnologies, Organic Chemicals and Polymers, thyssenkrupp Industrial Solutions, Bad Soden am Taunus, Germany
4:00 PM
Contract to accelerate? The economics to build or contract a pilot plant
Chad Pastor, Michigan State University Bioeconomy Institute, Lansing, MI
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