A scaled-down systems biology-driven approach to bioprocess development and commercializatio

Genomatica has established an integrated, systems-biology based technology platform to rapidly design, characterize and improve industrial microorganisms and bioprocesses. Achieving commercial targets requires a “whole process” approach, with parallel optimization of the organism, the fermentation process, and downstream product recovery. As the design of the integrated process evolves, the bottlenecks in the organism can shift, and vice versa. Changes to the strain and process, in turn, can impact the predictability of small-scale assays. This challenge has been solved by the development of a rigorous, quantitative, and flexible small-scale culturing approach. This talk will present examples of how diagnostic experiments at the well-plate and fermentation scale are applied in conjunction with systems biology tools, to identify pathway bottlenecks, guide the design of a variety of organisms and processes, and ultimately enable commercialization.