General purposing synthetic biology: A BioFoundry in a box

What would you do with unlimited DNA?  What could you build?  Productivity of DNA synthesis continues to increase at exponential rates. The oligonucleotide synthesis market alone is forecasted to reach nearly $2B USD by 2020 with an annual growth rate in excess of 10%. This increase in oligo synthesis capacity and reduction in associated costs is transforming synthetic biology; making the impossible not only possible, but routine.  Muse’s foundational technology is a proprietary synthetic biology platform that scales directly with oligo synthesis, enabling in vivo DNA synthesis at 100X lower cost than state of the art. To date, Muse has demonstrated gene editing at over 50,000 loci simultaneously. Applications include sequence to activity mapping for site saturation mutagenesis, protein and pathway engineering, strain reconstruction of complex evolved strains, and combinations thereof.  Editing capabilities have been demonstrated in a variety of industrially relevant organisms and include applications in industrial biotechnology and the pharmaceutical industry. Further, this technology has been automated in the form of a bench-top device that allows a single user to perform a broad range of molecular biology endeavors at rates 1000x beyond the current state of the art.