ambr250™: advanced tools for automated process development, optimisation and scale-up in both microbial and cell cultures for biotherapeutics

Challenges in upstream process development and optimization include; how to explore sufficient cell lines or microbial strain candidates, and develop optimal process pathways. To do this design of experiment analysis (DOE) with a suitable power number would be required. These experiments entail large laboratory space, high capital investment and significantly high FTE and can be time consuming.

TAP Biosystems (Full subsidiary of Sartorius) developed the advanced microbioreactor (ambr) technology that has now been widely adopted as a rapid cell line selection and early stage cell culture optimization tool. This was now followed by development ambr250, a tool that is now being used for process development and optimization both cell cultures and microbial fermentation.

In this session we present an overview of ambr250 technology, industry derived data that demonstrates the suitability of the technology in process development and scale-up in biotherapeutics and conclude by demonstrating the benefits that users acquire from obtaining the technology