Session 30: Applications of Protein Engineering in Biocatalysis
Thursday, July 24, 2014: 2:00 PM-5:30 PM
Regency Ballroom B, Second Floor (St. Louis Hyatt Regency at the Arch)
Convener:
Gregg T. Beckham - National Renewable Energy Laboratory, Golden, CO
Co-Convener:
Patrick C. Cirino - University of Houston, Houston, TX
Theoretical and computational methods are becoming essential to accelerating understanding and making improvements to enzyme function, as highlighted recently by the 2013 Nobel Prize in Chemistry. Recent work has even demonstrated that computational methods can be used in close concert with experimental approaches to design enzymes with new function. This session will cover applications of computation and theory to all aspects of industrial enzymology. Contributions focused on simulation approaches to examine structure-function relationships, computational methods to improve properties of interest, or in computational enzyme design are welcome.

2:00 PM
S151
Biosynthetic production of esters: Fundamental studies of the key pathway enzyme, alcohol acetyltransferase
Jie Zhu1, Jyun-Liang Lin2, Leidy Palomec2 and Ian Wheeldon2, (1)Biochemistry, UC Riverside, Riverside, CA, (2)Chemical and Environmental Engineering, UC Riverside, Riverside, CA
2:30 PM
S152
Optimized high-throughput screening of regulatory protein libraries for novel molecular biosensors
Patrick C. Cirino, Christopher S. Frei and Shuai Qian, Chemical Engineering, University of Houston, Houston, TX
3:30 PM
S153
Use of a novel combinatorial genetics platform to rapidly clone, express and select target biocatalytic activities for multigenic metabolic pathway optimization
Ian Fotheringham, Ingenza, Roslin, United Kingdom
4:00 PM
S154
Elimination of hydrogenase post-translational modification blocks H2 production and increases ethanol yield in Clostridium thermocellum
Ranjita Biswas1, Charlotte M. Wilson1, Tianyong Zheng2, Richard J. Giannone1, Dawn M. Klingeman1, Robert L. Hettich3, Daniel Olson2, Steven D. Brown1, Lee Lynd2 and Adam M. Guss1, (1)Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, (2)Thayer School of Engineering, Dartmouth College, Hanover, NH, (3)Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN
4:30 PM
S155
Bioprospecting for bacterial oligosaccharyltransferases with relaxed acceptor site specificity
Yi Chai1, Cassandra M. B. Guarino2, Anne A. Ollis1 and Matthew P. DeLisa1, (1)School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, (2)Department of Biomedical Engineering, Cornell University, Ithaca, NY
YC_SIMB2014.pdf
See more of: Invited Oral Papers
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