Session 8: Applications of Protein Engineering in Metabolic Engineering
Tuesday, July 22, 2014: 8:00 AM-11:30 AM
Regency Ballroom C, Second Floor (St. Louis Hyatt Regency at the Arch)
Conveners:
Ajikumar Parayil - Manus Biosynthesis, Cambridge, MA and Patrick C. Cirino - University of Houston, Houston, TX
Protein engineering plays an increasingly important role in metabolic engineering activities. While the toolbox of known proteins and their functions is vast and growing, metabolic engineers often seek proteins having combinations of properties not known to already exist. This session will highlight recent successes in the design of enzymes and other proteins for specific metabolic engineering applications. Engineering examples include (but are not limited to): enzymes or transport proteins having altered substrate/cofactor specificities, multi-protein complexes that enhance metabolic flux, regulatory proteins with modified control over gene expression, enhanced tolerance to non-native host environments, and novel activities allowing for assembly of non-natural metabolic pathways.

8:00 AM
S41
Evolutionary engineering of cellobiose transporters for enhanced cellobiose fermentation
Suk Jin Ha, Department of Bioengineering and Technology, Kangwon National University, Chuncheon, South Korea, Jonathan M. Galazka, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, Jamie H.D. Cate, Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA and Yong-Su Jin, Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL
8:30 AM
S42
Application of Codexis enzyme engineering technology towards a variety of industrial processes
Dipnath Baidyaroy, Business Development, Codexis, Inc., Redwood City, CA
9:00 AM
S43
Mitochondrial Engineering: Harnessing the Powerhouse of the Cell for the Production of Fuels and Chemicals
Jose L. Avalos, Chemical Engineering, Massachusetts Institute of Technology/Whitehead Institute, Cambridge, MA
10:00 AM
S44
Laboratory evolution of synthetic biocatalysts for N-linked protein glycosylation
Matthew P. DeLisa, School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY
10:30 AM
S45
General approach to engineering ketol-acid reductoisomerase cofactor preference
Sabine Brinkmann-Chen1, Tilman Flock1, Jackson K.B. Cahn1, Christopher D. Snow1, Eric M. Brustad1, Peter Meinhold2, John A. McIntosh1, Liang Zhang1 and Frances H. Arnold1, (1)Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, (2)Gevo, Inc., Englewood, CO
11:00 AM
S46
Leveraging machine learning for the systematic optimization of protein function
Claes Gustafsson, Sridhar Govindarajan, Mark Welch, Jeremy Minshull and Jon Ness, DNA2.0 Inc,, Menlo Park, CA
140721 SIMB public.pdf
See more of: Invited Oral Papers
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