S69: A "GoogleMAP"-type view of specialized molecules from microbes, their communities and hosts including people

Tuesday, August 13, 2013: 10:30 AM
Nautilus 4 (Sheraton San Diego)
Pieter C. Dorrestein, Theodore Alexandrov, Nuno Bandeira, Vanessa Phelan, Chris Rath, Amina Bouslimani, Carla Porto, Mingxun Wang, Yi Zeng, Yurong Guo and Kathleen Dorrestein, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA
Chemical crosstalk between cell populations is a universal phenomena. The chemistry involved in this crosstalk is very diverse and therefore capturing this information represents an analytical challenge especially since there are no amplification methods such as PCR used in sequencing that can be employed. In this talk we will highlight the mass spectrometry based workflows that the lab has developed to increase our ability to tease apart the molecular components of interacting microbes and microbial communities. In our lab we are referring to this as our “Google-Map streetview” for molecular space and it is captured in 2D as well as 3D. The examples highlighted in this talk will range from interacting microbes such as P. aeruginosa with C. albicans, microbial communities such as lichen, sputa from individuals with cystic fibrosis as well as molecular-microbial community maps of people.