Fees:
$375 SIM Member
$525 Non-Member
$188 Students
This workshop’s focus is to provide individuals with an introduction to fermentation concepts in industrial settings. The workshop will be lecture-based with visual aids to help the attendees understand the fermentation principles discussed. The workshop will be broken into sections based upon the topics that are being presented. After each section has been completed, the attendees will be given real life fermentation case studies that they will work through to reinforce the just discussed topics. The first section of the workshop will include topics on fermenter design including aspect ratios, agitator design, sparger design and sterilization of equipment and media. The second section will deal with actual operational issues of fermentation processes. Included will be discussions about media considerations, foam control strategies, shear, mixing, aeration, feeds and different types of fermentations and the controls involved. The workshop will finish with a section that covers issues involved in scale-up to production size fermentors.
Workshop Schedule
8:00am
Fermentation Introduction
Aerobic
Anaerobic
Fermentation Organisms
Bacteria
Yeast
Filamental fungus
Microbial Growth & Production
Growth measurement methods
Basic kinetics
Production systems
Problem Set #1
Fermentation Media
Carbon sources
Nitrogen sources
Trace elements
Fermentation Methods
Batch
Fed-Batch
Continuous
Problem Set #2
Types of Fermenters Airlift
Stirred
Fermentation Equipment
Agitation
Spargers
Cooling
pH probes
DO probes
Sterilization
Basics
Methods
Problem Set #3
9:30 am Break
Agitation/Mixing Impellers
Power input
Shear input
Problem Set #4
Aeration
Gassing strategies
Flooding
Entrainment
Effect on agitation
Oxygen transfer
Oxygen uptake measurement
Carbon dioxide evolution
Problem Set #5
Noon – 1 pm Lunch
1:00 PM
Fermenter Mass Balance
Fermenter Energy Balance
Problem Set #6
Fermentation Scaling
Strategies
Benefits/ challenges
2:30 pm Break
3:00 Case Study
4:00 Conclusion
Mark Berge
2010-Current: Sr. Scientist at MedImmune, Inc. in the Process Cell Culture & Fermentation group leading a team responsible for fermentation and cell culture process development activities. 2006-2010: Sr. Scientist at Amgen Inc. in Cell Science & Technology group developing processes for therapeutic protein production using fermentation. 1999-2005: Sr. Scientist at Pfizer Inc. in Global Biologics division developing processes for therapeutic protein production using cell culture. 1995-1999: Process Engineer at FermPro Manufacturing in deep tank toll manufacturing for varied customers of food grade materials. Mark holds a B.S. and M.S. in Chemical Engineering from the University of New Hampshire.
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