Natural Products - Natural products from unusual sources

Thursday, August 16, 2012: 2:00 PM-5:30 PM
Meeting Room 6, Columbia Hall, Terrace level (Washington Hilton)
David Newman
Antibiotics in the widest sense of the term have usually been found from terrestrial sources via fermentation, but the search using microbes has dwindled due to “finding the same old, same old compounds”. However, with the discovery that microbes have significant numbers of “cryptic secondary metabolite clusters,” has come the realization that control of these clusters may well produce molecules that have not been reported from microbes, be they well studied or not even known previously. This symposium will help to show how modification of assays and fermentation conditions coupled to a knowledge of genomics may well be the “new frontier” in discovery, utilizing sources old and new.

2:00 PM
Accessing novel chemistry from fungi
Cedric Pearce, Mycosynthetix, Inc., Hillsborough, NC
2:30 PM
Small molecule perimeter defense in entomopathogenic bacteria
Jason M. Crawford, Chemistry, Chemical Biology Institute, Yale University, West Haven, CT, Cyril Portmann, Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA, Xu Zhang, Chemistry & Chemical Biology, Harvard University, Cambridge, MA, Maarten Roeffaers, Microbial and Molecular Systems, Katholieke Universiteit Leuven, Heverlee, Belgium and Jon Clardy, Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA
3:00 PM
3:30 PM
Panamanian marine cyanobacteria as a source for new drug leads: discovery and development of santacruzamate A, a selective and potent histone deacetylase inhibitor
Christopher M. Pavlik1, Christina Y.B. Wong2, Dioxelis D. Lopez2, Niclas Engene3, Kerry McPhail4, William Gerwick3 and Marcy J. Balunas1, (1)Division of Medicinal Chemistry Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, (2)INDICASAT, Panama City, Panama, (3)Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, (4)College of Pharmacy, Oregon State University, Corvallis, OR
4:30 PM
Culture independent approaches for the discovery of new bacterial metabolites
Sean F. Brady, Rockefeller University, New York, NY
5:00 PM
In-silico approaches to natural product drug discovery
Josep Prous Jr., Research & Development, Prous Institute for Biomedical Research, Barcelona, Spain
See more of: Invited Oral Papers
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