Monday, August 13, 2012: 1:00 PM-4:30 PM
Jefferson West, Concourse Level (Washington Hilton)
Convener:
Douglas A. Mitchell
1:00 PM
Plant natural products as bacterial biofilm inhibitors
Mark O'Neil-Johnson and Gary Eldridge, Sequoia Sciences, Inc., Saint Louis, MO
Mark O'Neil-Johnson and Gary Eldridge, Sequoia Sciences, Inc., Saint Louis, MO
1:30 PM
Oxidative C-C deoxysugar cleavage in baumycin biosynthesis
Brian O. Bachmann1, Hung-wen Liu2 and Ahmad Al-Mestarihi1, (1)Chemistry, Vanderbilt University, Nashville, TN, (2)College of Pharmacy, University of Texas at Austin, Austin, TX
Brian O. Bachmann1, Hung-wen Liu2 and Ahmad Al-Mestarihi1, (1)Chemistry, Vanderbilt University, Nashville, TN, (2)College of Pharmacy, University of Texas at Austin, Austin, TX
2:00 PM
Divergent evolution of multimodular polyketide synthases revealed through the architecture of a ketoreductase-enoylreductase didomain
Adrian Keatinge-Clay1, Jianting Zheng1, Darren Gay1, Borries Demeler2 and Mark A. White3, (1)Chemistry and Biochemistry, The University of Texas at Austin, Austin, TX, (2)Biochemistry, The University of Texas Health Science Center at San Antonio, San Antonio, TX, (3)Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston, Galveston, TX
Adrian Keatinge-Clay1, Jianting Zheng1, Darren Gay1, Borries Demeler2 and Mark A. White3, (1)Chemistry and Biochemistry, The University of Texas at Austin, Austin, TX, (2)Biochemistry, The University of Texas Health Science Center at San Antonio, San Antonio, TX, (3)Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston, Galveston, TX
3:00 PM
Chemical genetic profiling and discovery of kibdelomycin, a potent new class of bacterial type II topoisomerase inhibitor
Sheo Singh, Discovery Chemistry, Merck Research Laboratories, Rahway, NJ
Sheo Singh, Discovery Chemistry, Merck Research Laboratories, Rahway, NJ
3:30 PM
Structural and functional studies of emerging polyheterocyclic antibiotics
Douglas A. Mitchell1, Katie J. Molohon2, Joel O. Melby3, Jaeheon Lee3 and Caitlin D. Deane3, (1)Chemistry and Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL, (2)Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL, (3)Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL
Douglas A. Mitchell1, Katie J. Molohon2, Joel O. Melby3, Jaeheon Lee3 and Caitlin D. Deane3, (1)Chemistry and Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL, (2)Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL, (3)Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL
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