Troubleshooting and mitigating the severe impact of a raw material lot-to-lot variability on the performance of a commercial fermentation process used for producing therapeutic proteins
Hedieh Barkhordarian¹, Kirsten Lewus² and Xiaoming (Jerry) Yang¹, (1)Cell Science and Technology, Amgen Inc., Thousand Oaks, CA, (2)Cell Science and Technology, Amgen Inc., Longmont, CO

Improvement of biotransformation and natural product yields by medium and process optimization
Thomas Tully, William Parker, Yande Huang, Qingmei Ye, Steve Chen, Michael Montana, Mark Liu, James Bergum, Steven Schwarz, Susan Durand, Jeff Howell, Paul Cino, Ramesh Patel and Animesh Goswami, Bristol-Myers Squibb, New Brunswick, NJ

Consistent bioprocess development in scaled-down fed-batch cultivation systems: combining suitable hardware and software approaches
Stefan Junne and Peter Neubauer, Dept. of Biotechnology, Chair of Bioprocess Engineering, Technische Universitaet Berlin, Berlin, Germany

Break

Automated on-line sampling and nutrient monitoring: a solution for optimizing fed-batch culture performance
William Miller¹, Cris Blattner², Dmitiry Shevchenko², Fred Blattner² and Michael Biksacky¹, (1)Flownamics, Inc., Madison, WI, (2)Scarab Genomics, LLC, Madison, WI

Design of experiments for fermentation processes
Donald W. McCormack Jr., SAS Institute, Austin, TX

FeedBeads: one way to enhance the reproducibility of pre-cultures in shake flasks
David Laidlaw¹, Tibor Anderlei², Robert Huber³ and Jochen Buchs³, (1)Kuhner Shaker Inc., San Carlos, CA, (2)Head of Science and Business Development, Adolf Kuhner AG, Birsfelden (Basel), Switzerland, (3)Biochemical Engineering, RWTH Aachen University, Aachen, Germany