Biocatalysis - Chemo-enzymatic approaches for product synthesis

Monday, August 13, 2012: 1:00 PM-4:30 PM
Meeting Room 11-12, Columbia Hall, Terrace level (Washington Hilton)
Sylvie Garneau-Tsodikova

1:00 PM
Employing polyketide synthase enzymes as biocatalysts to generate chiral building blocks
Adrian Keatinge-Clay, Andrew D. Harper, Constance B. Bailey, Darren C. Gay, Amanda J. Hughes and Shawn K. Piasecki, Chemistry and Biochemistry, The University of Texas at Austin, Austin, TX
1:25 PM
The biosynthesis of nucleoside antibiotics targeting bacterial translocase I
Steven G. Van Lanen, Pharmacy, University of Kentucky, Lexington, KY and Koichi Nonaka, Process Technology Research Lab., Dai-ichi Sankyo Co., Ltd., Fukushima, Japan
1:50 PM
Chemoenzymatic synthesis of bioengineered heparin
Robert J. Linhardt, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY
2:15 PM
2:45 PM
Chemoenzymatic synthesis of homogeneous ultra-low molecular weight heparins
Jian Liu, Division of Chemical Biology and Medicinal Chemistry, University of North Carolina, Chapel Hill, NC
3:10 PM
Mass spectrometry characterization for chemoenzymatic glycoprotein synthesis
John E. Schiel, Mark Lownthal and Karen W. Phinney, Analytical Chemistry, National Institute of Standards and Technology, Gaithersburg, MD
3:35 PM
Using small molecule probes to study the functional and structural interaction of adenylation and carrier protein domains in nonribosomal peptide synthetases
Courtney C. Aldrich1, Ce Shi1, Jesse A. Sundlov2, Carter A. Mitchell2 and Andrew M. Gulick2, (1)Center for Drug Design, University of Minnesota, Minneapolis, MN, (2)Hauptman-Woodward Medical Research Institute and Department of Structural Biology, State University of New York at Buffalo, Buffalo, NY
4:00 PM
Adenylation domains in formation of novel nonribosomal peptides
Sylvie Garneau-Tsodikova, Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI
See more of: Invited Oral Papers