In this talk examples will be given of innovative uses of high throughput sequencing technology to advance biological understanding as well as a description of our novel bioinformatics analysis platform Archetype. Archetype is a web service and software framework developed to manage the analysis of large quantities of metagenomic, microbial and eukaryotic biological sequence data. It has been developed over the last 4 years to meet the demands of a common analysis workflow carried out by scientists when working with biological sequence data. The workflow involves being able to rapidly query across disparate sequence based datasets, identify potential query hits and rapidly gather sequences for further analysis. All of these services can be exposed to an unlimited user group through an intuitive browser based user interface.