Biosynthetic engineering approaches to natural product lead optimization
Steve G. Kendrew, Biotica Technology Ltd., Cambridge, United Kingdom

Thailandepsins: Novel Bacterial Natural Products with Potent Histone Deacetylase Inhibition Activities and Promising Anticancer Activities
Yi-Qiang (Eric) Cheng, Department of Biological Sciences, Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI

Break

Merging Genomics, Mass Spectrometry, Bioinformatics and Biotechnology for Microbial Natural Product Discovery
Rolf Müller, Pharmaceutical Biotechnology, Saarland University, Saarbrücken, Germany

Triggering cryptic natural product biosynthesis in fungi
Kirstin Scherlach¹, Volker Schroeckh², Hans-Wilhelm Nützmann², Anindita Sarkar³, Julia Schümann¹, Axel A. Brakhage² and Christian Hertweck¹, (1)Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany, (2)Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany, (3)Bio Pilot Plant, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany

A sequence-based approach to natural product discovery
Paul R. Jensen, Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, La Jolla, CA